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PDGene - Polymorphism Details
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 Study: Haugarvoll, 2008
 Gene: USP24  (KIAA1057)  Entrez Gene
 Protein: ubiquitin specific protease 24  (deubiquitinating enzyme 24; ubiquitin thiolesterase 24; ubiquitin carboxyl-terminal hydrolase 24; ubiquitin-specific processing protease 24)  ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 17 December 2012
Meta-Analysis     Gene Overview
Total number of polymorphisms investigated by this study: 9

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   G-Allele C-Allele G/G
(frequency)
G/C
(frequency)
C/C
(frequency)
 Caucasian
rs13312 USA (Stage 3) PD
CTR
0.21
0.23
0.79
0.77
10 (0.045)
12 (0.054)
73 (0.330)
78 (0.353)
138 (0.624)
131 (0.593)
rs13312 Norway (Stage 1+3) PD
CTR
0.18
0.22
0.82
0.78
17 (0.032)
55 (0.048)
157 (0.296)
392 (0.343)
356 (0.672)
695 (0.609)
rs13312 Ireland (Stage 2+3) PD
CTR
0.21
0.27
0.79
0.73
7 (0.041)
13 (0.075)
57 (0.331)
68 (0.393)
108 (0.628)
92 (0.532)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs1043671 Norway (Stage 1) PD
CTR
0.04
0.05
0.96
0.95
0 (0.000)
0 (0.000)
14 (0.078)
17 (0.095)
166 (0.922)
162 (0.905)
rs1043671 Ireland (Stage 2+3) PD
CTR
0.04
0.05
0.96
0.95
0 (0.000)
0 (0.000)
15 (0.081)
17 (0.091)
170 (0.919)
169 (0.909)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs487230 USA (Stage 3) PD
CTR
0.25
0.27
0.75
0.73
14 (0.063)
16 (0.072)
83 (0.376)
87 (0.394)
124 (0.561)
118 (0.534)
rs487230 Norway (Stage 1+3) PD
CTR
0.22
0.27
0.78
0.73
26 (0.049)
83 (0.073)
182 (0.343)
450 (0.394)
322 (0.608)
609 (0.533)
rs487230 Ireland (Stage 2+3) PD
CTR
0.24
0.30
0.76
0.70
10 (0.058)
16 (0.092)
63 (0.364)
72 (0.416)
100 (0.578)
85 (0.491)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs683880 Norway (Stage 1) PD
CTR
0.27
0.26
0.73
0.74
13 (0.073)
12 (0.067)
71 (0.397)
69 (0.383)
95 (0.531)
99 (0.550)
rs683880 Ireland (Stage 2+3) PD
CTR
0.24
0.28
0.76
0.72
11 (0.059)
14 (0.075)
68 (0.364)
75 (0.403)
108 (0.578)
97 (0.522)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs667353 Norway (Stage 1) PD
CTR
0.41
0.40
0.59
0.60
31 (0.172)
29 (0.161)
87 (0.483)
87 (0.483)
62 (0.344)
64 (0.356)
rs667353 Ireland (Stage 2+3) PD
CTR
0.37
0.39
0.63
0.61
25 (0.134)
28 (0.151)
86 (0.462)
88 (0.473)
75 (0.403)
70 (0.376)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   T-Allele C-Allele T/T
(frequency)
T/C
(frequency)
C/C
(frequency)
 Caucasian
rs615652 Norway (Stage 1) PD
CTR
0.16
0.17
0.84
0.83
5 (0.028)
5 (0.028)
49 (0.272)
52 (0.289)
126 (0.700)
123 (0.683)
rs615652 Ireland (Stage 2+3) PD
CTR
0.16
0.18
0.84
0.82
5 (0.027)
6 (0.032)
50 (0.267)
55 (0.296)
132 (0.706)
125 (0.672)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   G-Allele A-Allele G/G
(frequency)
G/A
(frequency)
A/A
(frequency)
 Caucasian
rs1165226 Ireland (Stage 2+3) PD
CTR
0.36
0.40
0.64
0.60
22 (0.127)
28 (0.162)
80 (0.462)
83 (0.480)
71 (0.410)
62 (0.358)
rs1165226 USA (Stage 3) PD
CTR
0.41
0.40
0.59
0.60
37 (0.167)
35 (0.158)
107 (0.484)
106 (0.480)
77 (0.348)
80 (0.362)
rs1165226 Norway (Stage 1+3) PD
CTR
0.38
0.42
0.62
0.58
77 (0.145)
201 (0.176)
249 (0.470)
557 (0.488)
204 (0.385)
384 (0.336)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   G-Allele C-Allele G/G
(frequency)
G/C
(frequency)
C/C
(frequency)
 Caucasian
rs287235 Norway (Stage 1+3) PD
CTR
0.22
0.26
0.78
0.74
26 (0.049)
77 (0.067)
182 (0.343)
440 (0.385)
322 (0.608)
625 (0.547)
rs287235 USA (Stage 3) PD
CTR
0.26
0.28
0.74
0.72
15 (0.068)
17 (0.077)
85 (0.385)
89 (0.403)
121 (0.548)
115 (0.520)
rs287235 Ireland (Stage 2+3) PD
CTR
0.24
0.29
0.76
0.71
10 (0.058)
15 (0.087)
63 (0.364)
71 (0.410)
100 (0.578)
87 (0.503)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.

Case-Control Studies (by ethnic group)
  Genotypes*
Polymorphism ID#
(Link to NCBI)
Population   C-Allele T-Allele C/C
(frequency)
C/T
(frequency)
T/T
(frequency)
 Caucasian
rs6663252 Norway (Stage 1) PD
CTR
0.15
0.14
0.85
0.86
4 (0.022)
4 (0.022)
45 (0.250)
44 (0.243)
131 (0.728)
133 (0.735)
*Genotypes have been calculated from allele frequencies assuming Hardy-Weinberg equilibrium.
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Polymorphisms: 3446
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