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PDGene - Meta-Analysis of All Published PD Association Studies (Case-Control Only) rs6265
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 Polymorphism: rs6265 (V66M)
 Gene: BDNF  (MGC34632)  Entrez Gene    View on AlzGene   View on MSGene   View on SZGene
 Protein: brain-derived neurotrophic factor  (neurotrophin)  ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 27 November 2011
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  A-Allele
(frequency)
G-Allele
(frequency)
A/A
(frequency)
A/G
(frequency)
G/G
(frequency)
 Caucasian 7 PD
CTR
0.22
0.20
0.78
0.80
52 (0.039)
49 (0.038)
495 (0.370)
413 (0.322)
790 (0.591)
820 (0.640)
 Asian 7 PD
CTR
0.48
0.47
0.52
0.53
462 (0.229)
409 (0.213)
998 (0.494)
973 (0.508)
560 (0.277)
534 (0.279)
 Other/Mixed 1 PD
CTR
0.19
0.15
0.81
0.85
6 (0.060)
3 (0.022)
26 (0.260)
36 (0.265)
68 (0.680)
97 (0.713)
Total 15 PD
CTR
0.37
0.35
0.63
0.65
520 (0.150)
461 (0.138)
1519 (0.439)
1422 (0.427)
1418 (0.410)
1451 (0.435)

Meta-Analysis Methods      * New * Cumulative Meta-analysis
2) Forest plot for polymorphism  rs6265 (V66M)

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

BDNF_-1331C/T
BDNF_712G/A
D11S4115
rs11267088 (2bpSTR)
rs16917204 (11757G/C)
rs2049046
rs3088390 (2bpSTR)

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Studies: 881
Genes: 915
Polymorphisms: 3446
Meta-analyses: 889
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