PDGene

Meta-Analysis of All Published PD Association Studies (Case-Control Only) rs6265

Polymorphism:

rs6265 (V66M)

Gene:

BDNF (MGC34632)

View on AlzGene View on MSGene View on SZGene

Protein:

brain-derived neurotrophic factor (neurotrophin)

Chromosome:

11 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 27 November 2011

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		A-Allele (frequency)	G-Allele (frequency)	A/A (frequency)	A/G (frequency)	G/G (frequency)
Caucasian	7	PD CTR	0.22 0.20	0.78 0.80	52 (0.039) 49 (0.038)	495 (0.370) 413 (0.322)	790 (0.591) 820 (0.640)
Asian	7	PD CTR	0.48 0.47	0.52 0.53	462 (0.229) 409 (0.213)	998 (0.494) 973 (0.508)	560 (0.277) 534 (0.279)
Other/Mixed	1	PD CTR	0.19 0.15	0.81 0.85	6 (0.060) 3 (0.022)	26 (0.260) 36 (0.265)	68 (0.680) 97 (0.713)
Total	15	PD CTR	0.37 0.35	0.63 0.65	520 (0.150) 461 (0.138)	1519 (0.439) 1422 (0.427)	1418 (0.410) 1451 (0.435)

Meta-Analysis Methods * New * Cumulative Meta-analysis

2) Forest plot for polymorphism rs6265 (V66M)

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

BDNF_-1331C/T
BDNF_712G/A
D11S4115
rs11267088 (2bpSTR)
rs16917204 (11757G/C)
rs2049046
rs3088390 (2bpSTR)