PDGene

Meta-Analysis of All Published PD Association Studies (Case-Control Only) MAPT_H1H2

Polymorphism:

MAPT_H1H2

Gene:

MAPT/STH (TAU; MTBT2; FTDP-17; FLJ31424; MSTD; PPND; DDPAC; MAPTL; MTBT1; STH/MAPT)

View on ALSGene View on AlzGene View on MSGene View on SZGene

Protein:

microtubule-associated protein tau/saitohin (microtubule-associated protein tau; saitohin)

Chromosome:

17 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 17 December 2012 ; Note that H1/H2-discriminating polymorphisms are meta-analyzed individually, as well as in a "pooled" meta-analysis combining all studies that report to have tested a H1H2-discriminating polymorphism. In addition to MAPT/STH, PLEKHM1 in 17q21 shows genome-wide significant effects in PDGene.

Polymorphism:

1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
			Alleles		Genotypes
	# Case-Control Samples		H2-Allele (frequency)	H1-Allele (frequency)	H2/H2 (frequency)	H2/H1 (frequency)	H1/H1 (frequency)
Caucasian	12	PD CTR	0.18 0.21	0.82 0.79	163 (0.035) 220 (0.051)	1339 (0.290) 1401 (0.324)	3123 (0.675) 2698 (0.625)
Asian	1	PD CTR	0.00 0.00	1.00 1.00	0 (0.000) 0 (0.000)	0 (0.000) 1 (0.005)	173 (1.000) 190 (0.995)
Other/Mixed	1	PD CTR	0.14 0.18	0.86 0.82	3 (0.029) 8 (0.060)	23 (0.223) 31 (0.233)	77 (0.748) 94 (0.707)
Total	14	PD CTR	0.17 0.20	0.83 0.80	166 (0.034) 228 (0.049)	1362 (0.278) 1433 (0.309)	3373 (0.688) 2982 (0.642)

Meta-Analysis Methods

2) Forest plot for polymorphism MAPT_H1H2

Please also see disclaimer for more information on these meta-analyses.

Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

chr17:41367654
chr17:41416612
hCV3202946
MAPT_108C/T (H1H2)
MAPT_110173G/A
MAPT_199deltaC (H1H2)
MAPT_-226C/G (H1H2)
MAPT_-349T/C (H1H2)
MAPT_-373G/C-MspI (H1H2)
MAPT_-373G/C-MspI (H1H2)
MAPT_-45A/G (H1H2)
MAPT_-568indel (H1-poly)
MAPT_-592indel (H1H2)
MAPT_-623indel (H1H2)
MAPT_-639C/T (H1-poly)
MAPT_H1H2
MAPT_H1H2
MAPT_H1-SNP12
MAPT_H1-SNP4
MAPT_H1-SNP5
MAPT_indel-intron10
MAPT_SNP-BanII-exon3 (H1H2)
MAPT_SNP-Tsp509I (exon13-H1H2)
rs10514889
rs11568305 (H1-SNP3/9iii)
rs11867549
rs12150242
rs12150530
rs12947764
rs1467966
rs1560310
rs16940758
rs16940799
rs16940806
rs17563965
rs17564829
rs17571857
rs17573266
rs17573509
rs17574005
rs17574040
rs17649641
rs17650417
rs1880753
rs1880756
rs1991556
rs2055797
rs2158257
rs2258689 (H1-SNP14)
rs2303867
rs242559
rs242928
rs2435200
rs2435214
rs2942167
rs35908989
rs3744456
rs3744457
rs3744460
rs41543317 (hCV2560324)
rs41543317
rs41543512
rs4792891
rs4792893
rs4792894
rs62063786 (SNP19)
rs62063787 (SNP20)
rs63750222 (97065C/T)
rs6503453
rs72293848 (2bpSTR-intron 9)
rs767057
rs8078967
rs8079215
rs878918
rs916896
rs9891103