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PDGene - Meta-Analysis of All Published PD Association Studies (Case-Control Only) MAPT_H1H2
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 Polymorphism: MAPT_H1H2
 Gene: MAPT/STH  (TAU; MTBT2; FTDP-17; FLJ31424; MSTD; PPND; DDPAC; MAPTL; MTBT1; STH/MAPT)  Entrez Gene    View on ALSGene   View on AlzGene   View on MSGene   View on SZGene
 Protein: microtubule-associated protein tau/saitohin  (microtubule-associated protein tau; saitohin)  ProteinLink
 Chromosome: 17   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 17 December 2012 ;  Note that H1/H2-discriminating polymorphisms are meta-analyzed individually, as well as in a "pooled" meta-analysis combining all studies that report to have tested a H1H2-discriminating polymorphism. In addition to MAPT/STH, PLEKHM1 in 17q21 shows genome-wide significant effects in PDGene.
Gene Overview
 Polymorphism:
1) Summary of Allele and Genotype Distribution of all Published Association Studies (by Ethnic Group)
      Alleles Genotypes
  # Case-Control
Samples
  H2-Allele
(frequency)
H1-Allele
(frequency)
H2/H2
(frequency)
H2/H1
(frequency)
H1/H1
(frequency)
 Caucasian 12 PD
CTR
0.18
0.21
0.82
0.79
163 (0.035)
220 (0.051)
1339 (0.290)
1401 (0.324)
3123 (0.675)
2698 (0.625)
 Asian 1 PD
CTR
0.00
0.00
1.00
1.00
0 (0.000)
0 (0.000)
0 (0.000)
1 (0.005)
173 (1.000)
190 (0.995)
 Other/Mixed 1 PD
CTR
0.14
0.18
0.86
0.82
3 (0.029)
8 (0.060)
23 (0.223)
31 (0.233)
77 (0.748)
94 (0.707)
Total 14 PD
CTR
0.17
0.20
0.83
0.80
166 (0.034)
228 (0.049)
1362 (0.278)
1433 (0.309)
3373 (0.688)
2982 (0.642)

Meta-Analysis Methods
2) Forest plot for polymorphism MAPT_H1H2

Please also see disclaimer for more information on these meta-analyses.


Meta-analyses have not been performed on the following polymorphisms since they lack published genotype data in at least four independent case-control samples, or the published genotype data was otherwise not eligible for inclusion (see methods for details):

chr17:41367654
chr17:41416612
hCV3202946
MAPT_108C/T (H1H2)
MAPT_110173G/A
MAPT_199deltaC (H1H2)
MAPT_-226C/G (H1H2)
MAPT_-349T/C (H1H2)
MAPT_-373G/C-MspI (H1H2)
MAPT_-373G/C-MspI (H1H2)
MAPT_-45A/G (H1H2)
MAPT_-568indel (H1-poly)
MAPT_-592indel (H1H2)
MAPT_-623indel (H1H2)
MAPT_-639C/T (H1-poly)
MAPT_H1H2
MAPT_H1H2
MAPT_H1-SNP12
MAPT_H1-SNP4
MAPT_H1-SNP5
MAPT_indel-intron10
MAPT_SNP-BanII-exon3 (H1H2)
MAPT_SNP-Tsp509I (exon13-H1H2)
rs10514889
rs11568305 (H1-SNP3/9iii)
rs11867549
rs12150242
rs12150530
rs12947764
rs1467966
rs1560310
rs16940758
rs16940799
rs16940806
rs17563965
rs17564829
rs17571857
rs17573266
rs17573509
rs17574005
rs17574040
rs17649641
rs17650417
rs1880753
rs1880756
rs1991556
rs2055797
rs2158257
rs2258689 (H1-SNP14)
rs2303867
rs242559
rs242928
rs2435200
rs2435214
rs2942167
rs35908989
rs3744456
rs3744457
rs3744460
rs41543317 (hCV2560324)
rs41543317
rs41543512
rs4792891
rs4792893
rs4792894
rs62063786 (SNP19)
rs62063787 (SNP20)
rs63750222 (97065C/T)
rs6503453
rs72293848 (2bpSTR-intron 9)
rs767057
rs8078967
rs8079215
rs878918
rs916896
rs9891103

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Polymorphisms: 3446
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