Table 2. Summary of the genetic loci showing evidence for linkage in the meta-analysis of
whole-genome scans by Rosenberger et al. (2007). Linkage regions highlighted here are based on
the results summarized in Table 2 of that paper. Meta-analysis (using the Genome Search Meta-Analysis
[GSMA] method) was applied to data from a total of five whole-genome linkage scans published at the
time across 862 families with 1384 affected subjects. Studies investigating Parkinsonian syndromes
other than PD or analyzing overlapping samples were excluded. For the meta-analysis, DNA markers were
allocated into bins of 30 cM and 60 cM. The approximate chromosomal intervals of the loci showing
nominal significant linkage are indicated by a red line on the respective chromosome graphs throughout
PDGene (example)."Previous studies"
refers to the publication included in Rosenberger et al (2007) that
previously reported a particular region to show evidence for genetic linkage ("n.a." indicates regions
for which no individual study reported linkage prior to the meta-analysis). Please consult the paper
by Rosenberger et al. (2007) for more details.
Note that studies published after 2004 were not included in the meta-analysis. Since then,
additional whole genome linkage screens have been performed (e.g. Foltynie, 2005; Krygowska-Wajs,
2005; Gao, 2009) some of which replicated the putative PD linkage regions above (e.g. 1p31 and 5q23),
or suggested new loci (e.g. 3q25; Gao, 2009) that require further replication and meta-analysis.
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