Manhattan plot combining association results from 7,123,928 random-effects meta-analyses based on a PDGene datafreeze of April 15th 2011. Many of the GWAS SNPs were imputed using the IMPUTE (v2.0) software based on HapMap (Rel #3) and 1000 Genomes Project (Pilot release, June 2010) European-descent reference panels. Sample-specific association results were computed with SNPTEST (v2.2), meta-analyses were performed in PLINK (v1.07). Meta-analysis results are plotted as -log10 P-values (y-axis) against physical chromosomal location (x-axis). Black and grey dots indicate results originating exclusively from GWAS datasets, while green dots are based on a combination of candidate- gene studies, supplemented by GWAS datasets (where applicable). Note that the y-axis is truncated at 1.0E-25 for better legibility. The plot was generated in R using "qqman".
***For a fully browsable version of this plot, please visit the PDGene track on the UCSC Genome Browser. This track can also be accessed by clicking anywhere within the specific chromosome regions on the plot.***