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PDGene - Overview of all published large-scale and genome-wide association studies in PD
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 Status: Updated 11 February 2013;  ** See Large Scale Study Methods **
View GWAS Meta-analysis
GWAS (genome-wide association studies)
              PD Cases Normal Controls  
Study Design Type Population Source Platform # of SNPs Genotype Data Publicly Available DX # Subjects
(GWAS)
# Subjects
(follow-up)
# Subjects
(GWAS)
# Subjects
(follow-up)
Featured Genes
 Caucasian
Do, 2011
CCGWAS GWAS: 23andMe, REP: IPDGC CL Illumina HumanHap550+522,782 No M342665842962415470  
Edwards, 2010
CCGWAS, and joint analysis of NINDS, CIDR, HIHG USA (HIHG) CL Illumina Infinium610/1M-Duo/HumanHap550491,376 No C604-619- Submit comment 
Fung, 2006
CCGWAS USA (NINDS) CL Illumina Human I & HumanHap300408,803 Yes C267-270- Submit comment 
Hamza, 2010
CCGWAS USA (NGRC) CL Illumina HumanOmni1-Quad811,597 Yes C2000-1986- Submit comment 
Liu, 2011
CCGWAS GWAS: USA (Ashkenazi), REP: NINDS,PROGENI/GenePD CL Illumina Human 610/660-quad525,124 No C26817821781658    
Maraganore, 2005
CC, FBATGWAS USA CL Perlegen 250K hap-tag198,345 Yes C443332443332 Submit comment 
Pankratz, 2008
* Recently Updated *
CCGWAS USA (PROGENI,GenePD-CIDR) CL Illumina HumanCNV370328,189 Yes C857-867- Submit comment 
Saad, 2010
CCGWAS France, UK (WTCCC), Australia CL,PO Illumina Human610-Quad492,929 No C1039323219847064 Submit comment 
Simon-Sanchez, 2009
* Recently Updated *
CCGWAS USA, Germany, UK CL,PO Illumina HumanHap240S/300/550463,185 Yes M1745345240474756 Submit comment 
Simon-Sanchez, 2011
CCGWAS Netherlands CL,PO Illumina Human660-Quad/Human610514,799 No U772-2024- Submit comment 
Spencer, 2010
CCGWAS UK (WTCCC2), France CL,PO Illumina Human660-Quad/1.2MDuo1,733,533 Yes C1705103951751984 Submit comment 
Srinivasan, 2009
CCGWAS USA CL MegAllele 20K cSNP14,111 No C187-187-  
 Asian
Satake, 2009
CCGWAS Japan CL Illumina HumanHap550435,470 No C1078933262815753 Submit comment 
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Other large-scale studies
              PD Cases Normal Controls  
Study Design Type Population Source Platform # of SNPs Genotype Data Publicly Available DX # Subjects
(GWAS)
# Subjects
(follow-up)
# Subjects
(GWAS)
# Subjects
(follow-up)
Featured Genes
 Caucasian
Allen, 2009
CCGWAS re-analysis Fung, 2006 CL See primary study391,787 No ----- Submit comment 
Allen, 2010
CCGWAS re-analysis Pankratz, 2008 CL See primary study334,225 No ----- Submit comment 
Bertoli-Avella, 2006
CC, FBATGWAS (STRs) Netherlands CL STRs (customized)56 No C456225568  
Broer, 2011
CCAnalysis of HSP10, 60, 70, 90 and HSF families Netherlands (Rotterdam-GWAS) PO Illumina HumanHap5503,828 No U123-5422-    
Edwards, 2011
CCGWAS re-analysis Fung, 2006, Pankratz, 2008, Edwards, 2011 CL See primary studies5,000 No -----  
Evangelou, 2007
CC, FBATGWAS re-analysis Maraganore, 2005 and Fung, 2006 CL See primary studies32,192 No ----- Submit comment 
Foltynie, 2005
CCGWAS (STRs, pooled) UK CL,PO STRs (customized)5,546 No C1951792191695  
Hamza, 2011
CCGWAIS (coffee) GWAIS: Hamza, 2010, REP: USA (PEG, PAGE, HIHG) CL,PO See primary study811,597 Yes C145810149311917  
IPDGC, 2011
CCGWAS-meta-analysis, and follow-up GWAS: Pankratz, 2008, Simon-Sanchez, 2009, Spencer, 2010, Saad, 2010, REP: Europe&USA CL,PO See primary studies7,689,524 No U53337053120199007 Submit comment 
IPDGC, 2011
CCFollow-up II of previous GWAS meta-analysis (IPDGC, 2011) GWAS: Pankratz, 2008, Simon-Sanchez, 2009, Spencer, 2010, Saad, 2010, REP: Europe&USA&23andMe   See primary studies7,689,524 No U533334261047938631  
Lesnick, 2007
CC, FBATGWAS re-analysis Maraganore, 2005 and Fung, 2006 CL See primary studies198,345 No -----  
Simon-Sanchez, 2007
CCGWAS re-analysis Fung, 2006 CL See primary study408,000 No ----- Submit comment 
Wan, 2009
CCGWAS re-analysis Fung, 2006 CL See primary studyn.g. No ----- Submit comment 
Wang, 2007
CC, FBATGWAS re-analysis Maraganore, 2005 and Fung, 2006 CL See primary studiesn.g. No -----  
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Design: “CC” (case-control), “FBAT” (family-based).
Type: “GWAS” (genome-wide association study); “STRs” (short tandem repeats).
Source: Source of case population -> “CL” (clinic-based), “PO” (population-based).
Platform: Please refer to orignal publication for exact description. “cSNP” (coding-region SNP).
# SNPs: Approximate number of polymorphisms covered.
DX: Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, e.g. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Featured Genes: Dropdown menu of genes highlighted (“featured”) in original publication as potential PD susceptibility genes/loci after completion of all analyses, e.g. replication in multiple samples.
(-) : No information provided/not applicable.
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Polymorphisms: 3446
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