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Overview of all published large-scale and genome-wide association studies in PD
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 Status: Updated 16 July 2010;  ** See Large Scale Study Methods **
GWAS (genome-wide association studies)
              PD Cases Normal Controls    
Study Design Type Population Source Platform # of SNPs Genotype Data Publicly Available DX # Subjects
(GWAS)		 # Subjects
(follow-up)		 # Subjects
(GWAS)		 # Subjects
(follow-up)		 Featured Genes Comment
 Caucasian
Edwards, 2010
CCGWAS, and joint analysis of NINDS, CIDR, HIHG USA (HIHG) CL Illumina Infinium610/1M-Duo/HumanHap550491,376 No C604-619-  
Fung, 2006
* Recently Updated *		CCGWAS USA (NINDS) CL Illumina Human I & HumanHap300408,803 Yes C267-270- Submit comment 
Maraganore, 2005
* Recently Updated *		CC, FBATGWAS USA CL Perlegen 250K hap-tag198,345 Yes C443332443332 Submit comment 
Pankratz, 2008
* Recently Updated *		CCGWAS USA (PROGENI,GenePD-CIDR) CL Illumina HumanCNV370328,189 Yes C857-867- Submit comment 
Simon-Sanchez, 2009
* Recently Updated *		CCGWAS USA, Germany, UK CL,PO Illumina HumanHap240S/300/550463,185 No M1745345240474756  
Srinivasan, 2009
CCGWAS USA CL MegAllele 20K cSNP14,111 No C187-187-  
 Asian
Satake, 2009
* Recently Updated *		CCGWAS Japan CL Illumina HumanHap550435,470 No C1078933262815753  
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Other large-scale studies
              PD Cases Normal Controls    
Study Design Type Population Source Platform # of SNPs Genotype Data Publicly Available DX # Subjects
(GWAS)		 # Subjects
(follow-up)		 # Subjects
(GWAS)		 # Subjects
(follow-up)		 Featured Genes Comment
 Caucasian
Allen, 2009
CCGWAS re-analysis Fung, 2006 CL See primary study391,787 No ----- Submit comment 
Allen, 2010
CCGWAS re-analysis Pankratz, 2008 CL See primary study334,225 No -----  
Bertoli-Avella, 2006
CC, FBATGWAS (STRs) Netherlands CL STRs (customized)56 No C456225568  
Evangelou, 2007
* Recently Updated *		CC, FBATGWAS re-analysis Maraganore, 2005 and Fung, 2006 CL See primary studies32,192 No ----- Submit comment 
Foltynie, 2005
CCGWAS (STRs, pooled) UK CL,PO STRs (customized)5546 No C1951792191695  
Gonzalez-Perez, 2009
CCGWAS re-analysis Fung, 2006 CL See primary study17,825 No -----    
Lesnick, 2007
CC, FBATGWAS re-analysis Maraganore, 2005 and Fung, 2006 CL See primary studies198,345 No -----  
Simon-Sanchez, 2007
CCGWAS re-analysis Fung, 2006 CL See primary study408,000 No C---- Submit comment 
Wan, 2009
CCGWAS re-analysis Fung, 2006 CL See primary studiesn.g. No -----  
Wang, 2007
CC, FBATGWAS re-analysis Maraganore, 2005 and Fung, 2006 CL See primary studiesn.g. No -----  
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Design: “CC” (case-control), “FBAT” (family-based)
Type: “GWAS” (genome-wide association study); “STRs” (short tandem repeats)
Source: Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
Platform: Please refer to orignal publication for exact description. “cSNP” (coding-region SNP)
# SNPs: Approximate number of polymorphisms covered.
DX: Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Featured Genes: Dropdown menu of genes highlighted (“featured”) in original publication as potential PD susceptibility genes/loci after completion of all analyses, e.g. replication in multiple samples.
(-) : No information provided/not applicable.
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