The Michael J. Fox Foundation for Parkinson's Research   Research   News & Events   Funding Programs   About Alzheimer Research Forum   Current Papers   ARF Recommends   Research News		Overview of all published large-scale and genome-wide association studies in PD  Status: Updated 8 July 2008;  ** See Large Scale Study Methods ** Overview of all published large-scale and genome-wide association studies in PD               PD Cases Normal Controls     Study Design Type Population Source Platform # of SNPs Genotype Data Publicly Available # Subjects (% women) DX Onset Age (range) Age (range) # Subjects (% women) Age (range) Featured Genes Comment  Caucasian Bertoli-Avella, 2006 CC, FBAT GWA (VNTR) Netherlands CL VNTR (customized) 56 No 62 (-) C 66.3 + 6.4 (-) - 568 (-) - GWA_14q32.2 GWA_9q34.3 Evangelou, 2007 CC, FBAT GWA (SNP) Re-analysis of Maraganore, 2005 and Fung, 2006 CL See Maraganore, 2005 and Fung, 2006 527-32,192 No - C - - - -   Foltynie, 2005 CC GWA (VNTR) UK PO VNTR (customized) 5546 No 374 (37%) C 62 (25-89) - 1914 (-) - GWA_1p31.3 Fung, 2006 CC GWA USA (NINDS) CL Illumina (Infinium I & HumanHap300) 408,000 Yes 267 (-) C - - 270 (-) 68 (55-88) BRDG1 DLG2 GLT25D2 GWA_10q11.21 GWA_11q11 GWA_16q23.1 GWA_22q13.31 GWA_4q35.2 GWA_7p12.3 NEGR1 ULK2 ZNF313 Lesnick, 2007 CC, FBAT GWA (SNP) Re-analysis of Maraganore, 2005 and Fung, 2006 CL See Maraganore, 2005 and Fung, 2006 1,195-14,60 No - C - - - -   Maraganore, 2005 CC, FBAT GWA USA CL Perlegen (250K hap-tag) 198,345 Yes 775 (40%) C 62 (31-94) 68 (33-96) 775 (47%) 66.5 (29-91) CDCP2 GALNT3 GWA_10q21.1 GWA_2q36.3 GWA_4q28.1 GWA_4q28.3 GWA_5p15.32 GWA_7p14.2 PASD1 PRDM2 SEMA5A Contact us if you are an author of an association study regarding this gene, and don't find your study in this table, or find errors in the representation of your study details. Design:  “CC” (case-control), “FBAT” (family-based) Type:  “GWA” (genome-wide association study); “CWA” (chromosome-wide association study); “LSA” (other large-scale association study); “cSNP” (coding-region SNP) Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based). Platform:  Please refer to orignal publication for exact description. # SNPs:  Approximate number of polymorphisms covered. Onset Age and Age:  Mean or median age at onset or examination, respectively. DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown). Featured Genes:  Dropdown menu of genes highlighted (“featured”) in original publication as potential PD susceptibility genes/loci after completion of all analyses, e.g. replication in multiple samples. (-) :  No information provided.
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