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Overview of all published large-scale and genome-wide association studies in PD
Status:
Updated 8 July 2008
; **
See Large Scale Study Methods
**
Overview of all published large-scale and genome-wide association studies in PD
PD Cases
Normal Controls
Study
Design
Type
Population
Source
Platform
# of SNPs
Genotype Data Publicly Available
# Subjects
(% women)
DX
Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Featured Genes
Comment
Caucasian
Bertoli-Avella, 2006
CC, FBAT
GWA (VNTR)
Netherlands
CL
VNTR (customized)
56
No
62
(-)
C
66.3 + 6.4
(-)
-
568
(-)
-
GWA_14q32.2
GWA_9q34.3
Evangelou, 2007
CC, FBAT
GWA (SNP)
Re-analysis of Maraganore, 2005 and Fung, 2006
CL
See Maraganore, 2005 and Fung, 2006
527-32,192
No
-
C
-
-
-
-
 
Foltynie, 2005
CC
GWA (VNTR)
UK
PO
VNTR (customized)
5546
No
374
(37%)
C
62
(25-89)
-
1914
(-)
-
GWA_1p31.3
Fung, 2006
CC
GWA
USA (NINDS)
CL
Illumina (Infinium I & HumanHap300)
408,000
Yes
267
(-)
C
-
-
270
(-)
68
(55-88)
BRDG1
DLG2
GLT25D2
GWA_10q11.21
GWA_11q11
GWA_16q23.1
GWA_22q13.31
GWA_4q35.2
GWA_7p12.3
NEGR1
ULK2
ZNF313
Lesnick, 2007
CC, FBAT
GWA (SNP)
Re-analysis of Maraganore, 2005 and Fung, 2006
CL
See Maraganore, 2005 and Fung, 2006
1,195-14,60
No
-
C
-
-
-
-
 
Maraganore, 2005
CC, FBAT
GWA
USA
CL
Perlegen (250K hap-tag)
198,345
Yes
775
(40%)
C
62
(31-94)
68
(33-96)
775
(47%)
66.5
(29-91)
CDCP2
GALNT3
GWA_10q21.1
GWA_2q36.3
GWA_4q28.1
GWA_4q28.3
GWA_5p15.32
GWA_7p14.2
PASD1
PRDM2
SEMA5A
Contact us
if you are an author of an association study regarding this gene, and don't find your study in this table, or find errors in the representation of your study details.
Design:
“CC” (case-control), “FBAT” (family-based)
Type:
“GWA” (genome-wide association study); “CWA” (chromosome-wide association study); “LSA” (other large-scale association study); “cSNP” (coding-region SNP)
Source:
Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
Platform:
Please refer to orignal publication for exact description.
# SNPs:
Approximate number of polymorphisms covered.
Onset Age and Age:
Mean or median age at onset or examination, respectively.
DX:
Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Featured Genes:
Dropdown menu of genes highlighted (“featured”) in original publication as potential PD susceptibility genes/loci after completion of all analyses, e.g. replication in multiple samples.
(-)
: No information provided.
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