PDGene

Gene overview of all published PD-association studies for DRD2

Gene:

DRD2 (D2R; D2DR)

View on SZGene

Protein:

DRD2 dopamine receptor D2

Chromosome:

11 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 2 October 2011

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Costa-Mallen, 2000	Overlaps with Kelada, 2002	CL	1 (detail)	152 (39%)	C	-	-	231 (35%)	-	Trend
De Palma, 2010	Overlaps with Dick, 2007	CL	1 (detail)	767 (44%)	C	-	69.8 + 9.2 (-)	1989 (47%)	69.8 + 10 (-)	n.a.
Dick, 2007	Europe	CL	1 (detail)	767 (44%)	C	61.6 + 9.9 (-)	69.8 + 9.2 (-)	1989 (47%)	69.8 + 10 (-)	Negative
Kelada, 2002	USA	CL	1 (detail)	186 (39%)	C	-	69.7 + 9.3 (37-88)	296 (35%)	69.1 + 8.6 (44-84)	Negative
Maude, 2001	UK	CL	1 (detail)	260 (37%)	M	-	73 (41-92)	464 (50%)	59 (13-94)	Negative
McGuire, 2011	USA (PEGASUS)	CL,PO	5 (detail)	1035 (-)	U	-	-	1279 (-)	-	Negative
Oliveri, 1999	Italy	CL	1 (detail)	136 (44%)	C	-	65.8 + 8.8 (-)	224 (50%)	64 + 14.5 (-)	Positive
Oliveri, 2000	Italy	CL	3 (detail)	135 (56%)	C	-	65.8 + 8.8 (-)	202 (51%)	63.1 + 8 (-)	Positive
Pankratz, 2008	USA (PROGENI, GenePD)	CL	6 (detail)	857 (41%)	C	61.9 + 10.8 (-)	-	867 (60%)	54.8 + 13.1 (-)	Negative
Pastor, 1999	Spain	CL	1 (detail)	154 (44%)	C	-	56 + 11 (-)	125 (57%)	58 + 12 (-)	Negative
Plante-Bordeneuve, 1997	France & UK	CL	1 (detail)	118 (-)	C	-	-	100 (-)	-	Positive
Simon-Sanchez, 2009	USA (NINDS-GWAS)	CL	6 (detail)	931 (40%)	C	-	-	790 (58%)	-	Negative
African Descent
McGuire, 2011	USA (PEGASUS)	CL,PO	5 (detail)	29 (-)	U	-	-	66 (-)	-	Negative
Asian
Higuchi, 1995	Japan	CL	1 (detail)	70 (-)	C	-	67.1 + 9.8 (-)	70 (-)	67.1 + 10 (-)	Negative
McGuire, 2011	USA (PEGASUS)	CL,PO	5 (detail)	120 (-)	U	-	-	226 (-)	-	Negative
Mizuta, 2006	Japan	CL	3 (detail)	190 (-)	C	-	-	190 (-)	-	Negative
Nanko, 1994	Japan	CL	1 (detail)	71 (49%)	C	-	64.9 + 9.7 (40-84)	90 (48%)	27.8 + 6.4 (19-54)	Negative
Tan, 2003	Singapore	CL	1 (detail)	204 (44%)	C	-	64.4 + 10.3 (-)	216 (44%)	64.2 + 10 (-)	Negative
Hispanic
McGuire, 2011	USA (PEGASUS)	CL,PO	5 (detail)	141 (-)	U	-	-	164 (-)	-	Negative
Other/Mixed
Juyal, 2006	India (South)	CL	5 (detail)	147 (35%)	C	-	47.7 + 13.8 (-)	130 (35%)	58.2 + 12.3 (-)	Positive
Juyal, 2006	India (North)	CL	5 (detail)	340 (29%)	C	-	50.6 + 11.9 (20-78)	344 (28%)	57.3 + 9.9 (-)	Negative
Singh, 2008	India	CL	1 (detail)	70 (23%)	C	-	58.7 + 10.7 (22-82)	100 (23%)	53.8 + 9.6 (22-74)	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Maraganore, 2005	USA	3 (detail)	443	443 (39%)	C	61 (31-94)	68 (33-96)	443 (52%)	66 (29-90)	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.