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PDGene - Gene overview of all published PD-association studies for DRD2
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 Gene: DRD2  (D2R; D2DR)  Entrez Gene    View on SZGene
 Protein: DRD2 dopamine receptor D2   ProteinLink
 Chromosome: 11   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 2 October 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      PD Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Costa-Mallen, 2000
Overlaps with
Kelada, 2002
CL  1  (detail)  152
(39%)
C--231
(35%)
-Trend
De Palma, 2010
Overlaps with
Dick, 2007
CL  1  (detail)  767
(44%)
C-69.8 + 9.2
(-)
1989
(47%)
69.8 + 10
(-)
n.a.
Dick, 2007
Europe CL  1  (detail)  767
(44%)
C61.6 + 9.9
(-)
69.8 + 9.2
(-)
1989
(47%)
69.8 + 10
(-)
Negative
Kelada, 2002
USA CL  1  (detail)  186
(39%)
C-69.7 + 9.3
(37-88)
296
(35%)
69.1 + 8.6
(44-84)
Negative
Maude, 2001
UK CL  1  (detail)  260
(37%)
M-73
(41-92)
464
(50%)
59
(13-94)
Negative
McGuire, 2011
USA (PEGASUS) CL,PO  5  (detail)  1035
(-)
U--1279
(-)
-Negative
Oliveri, 1999
Italy CL  1  (detail)  136
(44%)
C-65.8 + 8.8
(-)
224
(50%)
64 + 14.5
(-)
Positive
Oliveri, 2000
Italy CL  3  (detail)  135
(56%)
C-65.8 + 8.8
(-)
202
(51%)
63.1 + 8
(-)
Positive
Pankratz, 2008
USA (PROGENI, GenePD) CL  6  (detail)  857
(41%)
C61.9 + 10.8
(-)
-867
(60%)
54.8 + 13.1
(-)
Negative
Pastor, 1999
Spain CL  1  (detail)  154
(44%)
C-56 + 11
(-)
125
(57%)
58 + 12
(-)
Negative
Plante-Bordeneuve, 1997
France & UK CL  1  (detail)  118
(-)
C--100
(-)
-Positive
Simon-Sanchez, 2009
USA (NINDS-GWAS) CL  6  (detail)  931
(40%)
C--790
(58%)
-Negative
 African Descent
McGuire, 2011
USA (PEGASUS) CL,PO  5  (detail)  29
(-)
U--66
(-)
-Negative
 Asian
Higuchi, 1995
Japan CL  1  (detail)  70
(-)
C-67.1 + 9.8
(-)
70
(-)
67.1 + 10
(-)
Negative
McGuire, 2011
USA (PEGASUS) CL,PO  5  (detail)  120
(-)
U--226
(-)
-Negative
Mizuta, 2006
Japan CL  3  (detail)  190
(-)
C--190
(-)
-Negative
Nanko, 1994
Japan CL  1  (detail)  71
(49%)
C-64.9 + 9.7
(40-84)
90
(48%)
27.8 + 6.4
(19-54)
Negative
Tan, 2003
Singapore CL  1  (detail)  204
(44%)
C-64.4 + 10.3
(-)
216
(44%)
64.2 + 10
(-)
Negative
 Hispanic
McGuire, 2011
USA (PEGASUS) CL,PO  5  (detail)  141
(-)
U--164
(-)
-Negative
 Other/Mixed
Juyal, 2006
India (South) CL  5  (detail)  147
(35%)
C-47.7 + 13.8
(-)
130
(35%)
58.2 + 12.3
(-)
Positive
Juyal, 2006
India (North) CL  5  (detail)  340
(29%)
C-50.6 + 11.9
(20-78)
344
(28%)
57.3 + 9.9
(-)
Negative
Singh, 2008
India CL  1  (detail)  70
(23%)
C-58.7 + 10.7
(22-82)
100
(23%)
53.8 + 9.6
(22-74)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Maraganore, 2005
USA  3  (detail)  443443
(39%)
C61
(31-94)
68
(33-96)
443
(52%)
66
(29-90)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis ->  "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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