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PDGene - Gene overview of all published PD-association studies for PARK7
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 Gene: PARK7  (DJ1; DJ-1)  Entrez Gene
 Protein: Parkinson disease (autosomal recessive, early onset) 7  (DJ-1 protein)  ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 2 October 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      PD Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Chung, 2010
USA CL  4  (detail)  449
(35%)
-64.7
(23-88)
70.3
(44-90)
449
(35%)
71.8
(45-93)
Negative
De Marco, 2009
Italy CL  6  (detail)  294
(39%)
C56.2 + 11.2
(-)
64.5 + 10.5
(38-86)
298
(53%)
65.6 + 13.8
(40-96)
Positive
Eerola, 2004
Finland CL  1  (detail)  147
(41%)
C-67.2
(38-88)
137
(64%)
65.8
(37-87)
Negative
Fung, 2006
Overlaps with
Simon-Sanchez, 2009 (USA)
CL  4  (detail)  267
(-)
C--270
(-)
68
(55-88)
Negative
Hedrich, 2004
Europe (mixed) CL  1  (detail)  300
(42%)
C38.3 + 7.2
(9-50)
-99
(-)
-Negative
Maraganore, 2004
Overlaps with
Chung, 2010 (USA)
CL  4  (detail)  691
(37%)
C63
(28-88)
68
(31-99)
190
(63%)
72
(37-94)
Negative
Morris, 2003
UK CL  1  (detail)  46
(-)
C-75 + 10
(40-90)
96
(-)
76 + 9
(61-100)
Negative
Nuytemans, 2009
Belgium CL  1  (detail)  310
(42%)
C60.1 + 11.3
(-)
-363
(47%)
67 + 10
(-)
n.a.
Pankratz, 2008
USA (PROGENI, GenePD) CL  13  (detail)  857
(41%)
C61.9 + 10.8
(-)
-867
(60%)
54.8 + 13.1
(-)
Negative
Simon-Sanchez, 2009
USA, Germany (GWAS) CL,PO  2  (detail)  1745
(45%)
C55.8
(7-98)
-4047
(50%)
-Negative
Simon-Sanchez, 2009
USA (NINDS-GWAS) CL  11  (detail)  931
(40%)
C--790
(58%)
-Negative
Sironi, 2010
Italy CL  1  (detail)  163
(-)
U--100
(-)
64 + 6.9
(-)
Negative
Sutherland, 2009
Australia CL  6  (detail)  331
(51%)
C60.1 + 10.6
(-)
70.3 + 8.7
(-)
296
(51%)
70.5 + 8.9
(-)
Negative
Tarantino, 2009
Overlaps with
Sironi, 2010
CL  3  (detail)  40
(-)
C35 + 8
(25-45)
38 + 7
(26-48)
100
(-)
74 + 7
(-)
Positive
 Asian
Mizuta, 2006
Japan CL  6  (detail)  190
(-)
C--190
(-)
-Negative
 Other/Mixed
Abou-Sleiman, 2003
Mixed CL  1  (detail)  375
(-)
M--210
(-)
-Trend
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Chung, 2010
USA  4  (detail)   654
(36%)
C60.4
(28-87)
66.3 + 30.8
(-)
654
(50%)
65.1
(32-90)
Negative
Maraganore, 2004
Overlaps with
Chung, 2010 (USA)
 4  (detail)  416416
(38%)
C61
(28-87)
67
(30-91)
416
(52%)
66
(40-89)
Positive
Maraganore, 2005
Overlaps with
Chung, 2010 (USA)
 5  (detail)  443443
(39%)
C61
(31-94)
68
(33-96)
443
(52%)
66
(29-90)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis ->  "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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