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Gene overview of all published PD-association studies for CYP2D6

Gene:

CYP2D6 (CPD6; MGC120390; MGC120389; CYP2D; CYP2D@; CYP2DL1; P450C2D; P450-DB1)

View on AlzGene View on MSGene View on SZGene

Protein:

cytochrome P450, family 2, subfamily D, polypeptide 6

Chromosome:

22 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 23 June 2010

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Agundez, 1995	Spain	CL	1 (detail)	123 (46%)	C	58.8 (28-80)	-	150 (45%)	32.6 + 12.5 (19-81)	Positive	Submit comment
Akhmedova, 1995	Russia	CL	1 (detail)	80 (-)	C	-	66 + 9.5 (-)	70 (-)	62.2 + 12 (-)	Positive	Submit comment
Armstrong, 1992	UK	CL	1 (detail)	53 (-)	C	-	72.3 + 11.4 (-)	72 (-)	-	Positive	Submit comment
Atkinson, 1999	UK	CL	1 (detail)	33 (-)	N	-	79 + 5.2 (70-90)	75 (-)	79.8 + 7.2 (70-104)	Positive	Submit comment
Bandmann, 1997	UK	CL	1 (detail)	200 (40%)	M	-	72.6 (-)	100 (35%)	77.1 + 8.8 (-)	Negative	Submit comment
Bialecka, 2007	Poland	CL	1 (detail)	134 (44%)	C	54.9 (-)	65.2 (-)	66 (44%)	77 + 4.9 (70-93)	Negative	Submit comment
Bon, 1999	Netherlands	CL	1 (detail)	199 (-)	M	-	-	96 (-)	-	Positive	Submit comment
Bordet, 1996	France	CL	1 (detail)	130 (50%)	C	-	67.1 + 10.1 (-)	159 (56%)	66.6 + 12.1 (-)	Negative	Submit comment
De Palma, 1998	Italy	CL	1 (detail)	100 (41%)	C	58.6 + 9.7 (-)	66.6 + 9.7 (-)	200 (41%)	64.2 + 9.2 (-)	Negative	Submit comment
De Palma, 2010	Overlaps with Dick, 2007	CL	1 (detail)	767 (44%)	C	-	69.8 + 9.2 (-)	1989 (47%)	69.8 + 10 (-)	n.a.
Deng, 2004	Australia	CL	1 (detail)	393 (42%)	C	60 + 11 (-)	67 + 10 (-)	389 (72%)	64 + 11 (-)	Positive	Submit comment
Dick, 2007	Europe	CL	1 (detail)	767 (44%)	C	61.6 + 9.9 (-)	69.8 + 9.2 (-)	1989 (47%)	69.8 + 10 (-)	Negative	Submit comment
Diederich, 1996	Luxembourg	CL	1 (detail)	80 (35%)	C	53.3 (-)	61.9 (-)	108 (-)	-	Negative	Submit comment
Elbaz, 2004	France	CO	1 (detail)	190 (44%)	C	64 + 7 (-)	-	419 (44%)	-	Negative	Submit comment
Gasser, 1996	Germany	CL	1 (detail)	115 (-)	C	-	62.9 (-)	73 (-)	63.2 (-)	Negative	Submit comment
Halling, 2008	Denmark	CL	1 (detail)	79 (46%)	C	65.4 + 10.7 (-)	74.4 + 9.5 (-)	154 (44%)	75.3 + 9.5 (46-91)	Negative	Submit comment
Harhangi, 2001	Netherlands	PO	1 (detail)	80 (64%)	C	-	77.3 + 8.3 (58-99)	156 (-)	76.6 + 8.3 (58-99)	Negative	Submit comment
Joost, 1999	USA	CL	1 (detail)	109 (-)	C	-	-	110 (-)	-	Negative	Submit comment
Kosel, 1996	Germany	CL	1 (detail)	21 (19%)	N	-	74.4 + 7.2 (62-85)	62 (-)	-	Negative	Submit comment
Kurth, 1993	USA	CL	1 (detail)	50 (-)	C	-	72 + 10 (-)	121 (-)	-	Positive	Submit comment
Lucotte, 1996	France	CL	1 (detail)	47 (49%)	C	65.6 + 9 (-)	-	47 (-)	-	Positive	Submit comment
Maraganore, 2000	USA	CL	1 (detail)	139 (35%)	C	62 (31-82)	69 (39-91)	113 (65%)	72 (37-90)	Negative	Submit comment
McCann, 1997	Australia	CL	1 (detail)	112 (38%)	C	61 + 9 (-)	69 + 9 (-)	206 (37%)	69 + 11 (-)	Negative	Submit comment
Nicholl, 1999	UK	CL	1 (detail)	206 (41%)	C	-	64.4 (-)	206 (41%)	63.1 (-)	Negative	Submit comment
Payami, 2001	USA	CL	1 (detail)	576 (36%)	C	57.5 + 12.3 (-)	68.1 + 10.5 (38-91)	247 (-)	73.6 + 8.2 (30-101)	Negative	Submit comment
Plante-Bordeneuve, 1994	Overlaps with Ray-Chaudhari, 1995	CL	1 (detail)	22 (-)	C	-	-	69 (-)	-	n.a.	Submit comment
Ray-Chaudhari, 1995	UK	CL	1 (detail)	272 (-)	C	-	-	720 (-)	-	Positive	Submit comment
Rempfer, 1994	UK	CL	1 (detail)	19 (-)	N	-	-	17 (-)	-	Positive	Submit comment
Sabbagh, 1999	France	CL	1 (detail)	109 (59%)	C	60 + 10.5 (-)	67.1 + 9.7 (-)	514 (-)	-	Negative	Submit comment
Sandy, 1996	USA	CL	1 (detail)	108 (-)	C	-	-	236 (-)	-	Negative	Submit comment
Smith, 1992	Overlaps with Ray-Chaudhari, 1995	CL	1 (detail)	229 (-)	C	-	-	720 (-)	-	n.a.	Submit comment
Stefanovic, 2000	Croatia	CL	1 (detail)	41 (46%)	C	-	62 (39-79)	145 (59%)	34 (19-54)	Positive	Submit comment
Takehashi, 2004	Overlaps with Tanaka, 1998	CL	1 (detail)	45 (-)	N	-	74.2 + 6.1 (-)	74 (-)	74.8 + 8.8 (-)	n.a.	Submit comment
Tanaka, 1998	USA	CL	1 (detail)	47 (-)	N	-	74.5 + 6.1 (-)	86 (-)	76.3 + 7.6 (-)	Positive	Submit comment
Vilar, 2007	Portugal	CL	1 (detail)	96 (-)	C	60.2 + 8.7 (38-77)	68.3 + 7.7 (46-85)	96 (-)	-	Positive	Submit comment
Asian
Chan, 1998	China	CL	1 (detail)	215 (47%)	C	-	-	313 (45%)	-	Negative
Chida, 1999	Japan	CL	1 (detail)	38 (-)	C	-	-	270 (-)	-	Negative
Ho, 1999	China	CL	1 (detail)	30 (-)	C	-	-	39 (-)	-	Positive	Submit comment
Lo, 1998	Taiwan	CL	1 (detail)	53 (23%)	C	-	69 (54-85)	94 (50%)	45 (-)	Negative	Submit comment
Pang, 1998	China	CL	1 (detail)	207 (48%)	C	-	-	227 (49%)	-	Negative
Woo, 2001	Korea	CL	1 (detail)	93 (-)	C	-	60.3 + 10.8 (-)	122 (-)	61.7 + 10.7 (-)	Negative	Submit comment
Other/Mixed
Singh, 2008	Overlaps with Singh, 2010	CL	1 (detail)	70 (23%)	C	-	58.7 + 10.7 (22-82)	100 (23%)	53.8 + 9.6 (22-74)	n.a.	Submit comment
Singh, 2010	India	CL	1 (detail)	77 (21%)	C	-	58.7 + 10.7 (22-82)	125 (24%)	53.8 + 9.6 (22-74)	Positive
Whilhelmsen, 1997	USA	CO	1 (detail)	121 (36%)	C	-	71.2 + 9.9 (41-91)	138 (63%)	74.4 + 6.6 (59-93)	Negative	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Plante-Bordeneuve, 1994	Overlaps with Ray-Chaudhari, 1995	1 (detail)	22	48 (-)	C	-	-	88 (-)	-	Trend	Submit comment
Sabbagh, 1999	France	1 (detail)	6	18 (356%)	C	51.4 + 15 (-)	-	50 (-)	-	Negative	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.