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PDGene - Gene overview of all published PD-association studies for HTR2A
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 Gene: HTR2A  (HTR2; 5-HT2A)  Entrez Gene    View on AlzGene   View on SZGene
 Protein: 5-hydroxytryptamine (serotonin) receptor 2A  (5-HT2 receptor)  ProteinLink
 Chromosome: 13   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 2 October 2011
1. Case-Control Studies (by ethnic group)
      PD Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
# Subjects
(% women)
Kiferle, 2007
Italy CL  1  (detail)  122
C61.4 + 10.9
64.3 + 10.2
Pankratz, 2008
USA (PROGENI, GenePD) CL  2  (detail)  857
C61.9 + 10.8
54.8 + 13.1
Shadrina, 2006
Russia CL  1  (detail)  97
C-60.1 + 12.3
Simon-Sanchez, 2009
USA, Germany (GWAS) CL,PO  2  (detail)  1745
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis ->  "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 881
Genes: 915
Polymorphisms: 3446
Meta-analyses: 889
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