PDGene

Gene overview of all published PD-association studies for PM20D1

Gene:

PM20D1 (PARK16; FLJ32569; Cps1)

Protein:

peptidase M20 domain containing 1

Chromosome:

1 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 2 October 2011 ; ***Note that in addition to PM20D1, the genes NUCKS1, SLC41A1, and SLC45A3 in PARK16 show genome-wide significant effects in PDGene. As statistical significance is currently weaker than for PM20D1, they are not listed in the top results, but can be accessed via the PDGene search function.***

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Pankratz, 2008	USA (PROGENI, GenePD)	CL	1 (detail)	857 (41%)	C	61.9 + 10.8 (-)	-	867 (60%)	54.8 + 13.1 (-)	Negative
Simon-Sanchez, 2009	USA, Germany (GWAS)	CL,PO	1 (detail)	1745 (45%)	C	55.8 (7-98)	-	4047 (50%)	-	Positive
Simon-Sanchez, 2009	USA, Germany, UK (Stage II)	CL,PO	1 (detail)	2816 (-)	M	-	-	3401 (-)	-	Negative
Simon-Sanchez, 2011	Netherlands (GWAS)	CL,PO	1 (detail)	772 (36%)	U	55.3 (16-84)	62.3 (29-89)	2024 (56%)	53.7 (45-95)	Negative
Asian
Satake, 2009	Japan (Replication-2)	CL	1 (detail)	321 (55%)	C	63.7 + 9.7 (-)	-	1614 (55%)	59.1 + 19.1 (-)	Positive
Satake, 2009	Japan (Replication-1)	CL	1 (detail)	612 (50%)	C	43 + 13.8 (20-80)	-	14139 (42%)	60.1 + 12.6 (-)	Positive
Satake, 2009	Japan (GWAS)	CL	1 (detail)	1078 (55%)	C	-	58.8 + 10.1 (22-88)	2628 (45%)	49.9 + 14.2 (-)	Positive
Tan, 2010	Singapore	CL	1 (detail)	433 (44%)	C	60 (-)	64 (-)	916 (40%)	56 (-)	Positive
Yan, 2011	China	CL	1 (detail)	226 (45%)	C	51.8 + 13.2 (9-83)	58.6 (-)	230 (46%)	-	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.