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Gene overview of all published PD-association studies for ATP13A2

Gene:

ATP13A2 (KRPPD; PARK9; HSA9947; FLJ26510)

Protein:

ATPase type 13A2 (putative ATPase; OTTHUMP00000002399)

Chromosome:

1 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 22 June 2010

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Fung, 2006	Overlaps with Simon-Sanchez, 2009 (USA)	CL	5 (detail)	267 (-)	C	-	-	270 (-)	68 (55-88)	Negative	Submit comment
Pankratz, 2008	USA (PROGENI, GenePD)	CL	4 (detail)	857 (41%)	C	61.9 + 10.8 (-)	-	867 (60%)	54.8 + 13.1 (-)	Negative	Submit comment
Rakovic, 2009	Germany	CL	2 (detail)	220 (30%)	C	60.1 + 9 (41-85)	-	232 (55%)	69.6 + 11.7 (41-99)	Negative	Submit comment
Rakovic, 2009	Germany, Serbia	CL	2 (detail)	161 (22%)	C	51.7 + 10.3 (40-80)	-	150 (35%)	53.9 + 10.8 (40-90)	Negative	Submit comment
Simon-Sanchez, 2009	USA, Germany (GWAS)	CL,PO	3 (detail)	1745 (45%)	C	55.8 (7-98)	-	4047 (50%)	-	Negative
Sutherland, 2009	Australia	CL	3 (detail)	331 (51%)	C	60.1 + 10.6 (-)	70.3 + 8.7 (-)	296 (51%)	70.5 + 8.9 (-)	Negative	Submit comment
Other/Mixed
Vilarino-Guell, 2008	Tunisia	CL	23 (detail)	240 (53%)	C	-	64 + 11 (25-85)	372 (50%)	56 + 11 (29-90)	Negative	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.