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Gene overview of all published PD-association studies for GWA_7p14.2

Gene:

GWA_7p14.2 (rs17329669)

Protein:

unknown

Chromosome:

7 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 29 June 2010 ; ***This locus was identified via a Genome-wide Association study (GWA) analysis and has not yet been assigned to a specific gene***

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Elbaz, 2006	Germany (Kruger)	CL	1 (detail)	834 (57%)	C	-	64.2 (-)	1192 (58%)	57.7 (-)	Negative	Submit comment
Elbaz, 2006	Australia (Mellick)	CL	1 (detail)	545 (40%)	C	-	70.9 (-)	446 (59%)	69.2 (-)	Negative	Submit comment
Elbaz, 2006	Italy (Annesi)	CL	1 (detail)	200 (42%)	C	-	69.4 (-)	200 (54%)	72.5 (-)	Negative	Submit comment
Elbaz, 2006	Belgium (Van Broeckhoven)	CL	1 (detail)	271 (42%)	C	-	67.7 (-)	278 (44%)	65.2 (-)	Negative	Submit comment
Elbaz, 2006	Greece (Hadjigeorgiou)	CL	1 (detail)	177 (43%)	C	-	70 (-)	155 (54%)	67.6 (-)	Negative	Submit comment
Elbaz, 2006	Sweden (Carmine)	CL	1 (detail)	119 (34%)	C	-	66.9 (-)	135 (47%)	67.7 (-)	Negative	Submit comment
Elbaz, 2006	Sweden (Wirdefeldt)	PO	1 (detail)	78 (50%)	C	-	74.6 (-)	118 (54%)	73.8 (-)	Negative	Submit comment
Elbaz, 2006	France (Elbaz)	PO	1 (detail)	209 (43%)	C	-	66.9 (-)	501 (41%)	66.9 (-)	Negative	Submit comment
Elbaz, 2006	Italy (Ferrarese)	CL	1 (detail)	100 (49%)	C	-	66.4 (-)	105 (43%)	60.9 (-)	Negative	Submit comment
Elbaz, 2006	USA (Marder-Mayeux)	CL,PO	1 (detail)	236 (-)	C	-	-	197 (-)	-	Negative	Submit comment
Elbaz, 2006	USA (Nelson)	PO	1 (detail)	478 (-)	C	-	-	524 (-)	-	Negative	Submit comment
Elbaz, 2006	USA (Payami)	CL	1 (detail)	1476 (-)	C	-	-	1818 (-)	-	Negative	Submit comment
Elbaz, 2006	USA (Ritz)	PO	1 (detail)	195 (-)	C	-	-	168 (-)	-	Negative	Submit comment
Farrer, 2006	Ireland	CL	1 (detail)	185 (-)	C	-	-	184 (-)	-	Negative	Submit comment
Farrer, 2006	Norway	CL	1 (detail)	324 (-)	C	-	-	332 (-)	-	Negative	Submit comment
Goris, 2006	UK	CL,CO	1 (detail)	538 (-)	C	63 (25-91)	-	516 (-)	-	Negative	Submit comment
Li, 2006	USA (NINDS)	CL	1 (detail)	311 (53%)	C	63.8 + 8.9 (50-87)	70.2 + 8.5 (52-92)	311 (53%)	70.1 + 8.5 (52-92)	Positive	Submit comment
Maraganore, 2005	USA	CL	1 (detail)	332 (42%)	C	63 (36-88)	68 (42-90)	332 (42%)	67 (42-91)	Positive	Submit comment
Sharma, 2008	Overlaps with Elbaz, 2006 (Germany)	CL	1 (detail)	663 (40%)	C	55.4 (-)	-	1002 (40%)	52 (-)	n.a.	Submit comment
Asian
Elbaz, 2006	Japan (Kawakami)	CL	1 (detail)	304 (52%)	C	-	68.8 (-)	464 (64%)	70.6 (-)	Negative	Submit comment
Other/Mixed
Elbaz, 2006	USA (Nelson)	PO	1 (detail)	119 (-)	C	-	-	115 (-)	-	Negative	Submit comment
Elbaz, 2006	USA (Marder-Mayeux)	CL,PO	1 (detail)	78 (-)	C	-	-	120 (-)	-	Negative	Submit comment
Elbaz, 2006	USA (Ritz)	PO	1 (detail)	29 (-)	C	-	-	30 (-)	-	Negative	Submit comment
Elbaz, 2006	USA (Payami)	CL	1 (detail)	78 (-)	C	-	-	116 (-)	-	Negative	Submit comment
Farrer, 2006	USA	CL	1 (detail)	247 (-)	C	-	-	253 (-)	-	Negative	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Maraganore, 2005	USA	1 (detail)	443	443 (39%)	C	61 (31-94)	68 (33-96)	443 (52%)	66 (29-90)	Positive	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.