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Gene overview of all published PD-association studies for MAOB

Gene:

MAOB

View on AlzGene View on SZGene

Protein:

amine oxidase (flavin-containing) (MAO, brain; MAO, platelet; tyramine oxidase; adrenalin oxidase)

Chromosome:

X (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 16 July 2010

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Bialecka, 2005	Poland (Men)	CL	1 (detail)	112 (0%)	C	-	-	75 (0%)	-	Positive	Submit comment
Bialecka, 2005	Poland (Women)	CL	1 (detail)	98 (100%)	C	-	-	77 (100%)	-	Positive	Submit comment
Bialecka, 2007	Overlaps with Bialecka, 2005 (Men)	CL	1 (detail)	75 (0%)	C	-	-	37 (0%)	-	n.a.	Submit comment
Bialecka, 2007	Overlaps with Bialecka, 2005 (Women)	CL	1 (detail)	59 (100%)	C	-	-	29 (100%)	-	n.a.	Submit comment
Checkoway, 1998	Overlaps with Kelada, 2002 (Men)	PO	1 (detail)	57 (0%)	C	-	-	89 (0%)	-	n.a.	Submit comment
Checkoway, 1998	Overlaps with Kelada, 2002 (Women)	PO	1 (detail)	41 (100%)	C	-	-	57 (100%)	-	n.a.	Submit comment
Costa, 1997	Overlaps with Kelada, 2002 (Men)	CL	1 (detail)	37 (0%)	C	-	-	50 (0%)	-	n.a.	Submit comment
Costa, 1997	Overlaps with Kelada, 2002 (Women)	CL	1 (detail)	25 (100%)	C	-	-	29 (100%)	-	n.a.	Submit comment
Costa-Mallen, 2000	Overlaps with Kelada, 2002 (Men)	CL	1 (detail)	92 (0%)	C	-	-	149 (0%)	-	n.a.	Submit comment
Costa-Mallen, 2000	Overlaps with Kelada, 2002 (Women)	CL	1 (detail)	60 (100%)	C	-	-	82 (100%)	-	n.a.	Submit comment
Costa-Mallen, 2004	Overlaps with Kelada, 2002 (Men)	CL	3 (detail)	96 (0%)	C	-	-	97 (0%)	-	Negative	Submit comment
Costa-Mallen, 2004	Overlaps with Kelada, 2002 (Women)	CL	2 (detail)	54 (100%)	C	-	-	60 (100%)	-	Negative	Submit comment
De Palma, 2010	Overlaps with Dick, 2007 (Europe-Men)	CL	1 (detail)	426 (0%)	C	-	-	1057 (0%)	-	n.a.
De Palma, 2010	Overlaps with Dick, 2007 (Europe-Women)	CL	1 (detail)	341 (100%)	C	-	-	932 (100%)	-	n.a.
Dick, 2007	Europe (Men)	CL	1 (detail)	426 (0%)	C	-	-	1057 (0%)	-	Negative	Submit comment
Dick, 2007	Europe (Women)	CL	1 (detail)	341 (100%)	C	-	-	932 (100%)	-	Negative	Submit comment
Fung, 2006	Overlaps with Simon-Sanchez, 2009 (USA-Men)	CL	2 (detail)	160 (0%)	C	-	-	128 (0%)	-	n.a.	Submit comment
Fung, 2006	Overlaps with Simon-Sanchez, 2009 (USA-Women)	CL	2 (detail)	102 (100%)	C	-	-	135 (100%)	-	Negative	Submit comment
Goudreau, 2002	USA (Men)	CL,PO	1 (detail)	197 (0%)	C	-	-	74 (0%)	-	Positive	Submit comment
Goudreau, 2002	USA (Women)	CL,PO	1 (detail)	122 (100%)	C	-	-	122 (100%)	-	Positive	Submit comment
Hernan, 2002	USA (Men)	CL	1 (detail)	98 (0%)	C	-	-	203 (0%)	-	Negative	Submit comment
Hernan, 2002	USA (Women)	CL	1 (detail)	116 (100%)	C	-	-	246 (100%)	-	Negative	Submit comment
Ho, 1995	UK (Men)	CL	1 (detail)	81 (0%)	C	-	-	48 (0%)	-	Negative	Submit comment
Ho, 1995	UK (Women)	CL	1 (detail)	43 (100%)	C	-	-	40 (100%)	-	Negative	Submit comment
Hotamisligil, 1994	USA (Men)	CL	1 (detail)	91 (0%)	C	-	-	129 (0%)	-	Positive	Submit comment
Kelada, 2002	USA (Men)	CL	1 (detail)	113 (0%)	C	-	-	193 (0%)	-	Positive	Submit comment
Kelada, 2002	USA (Women)	CL	1 (detail)	73 (100%)	C	-	-	103 (100%)	-	Positive	Submit comment
Kurth, 1993	USA (Men)	CL	1 (detail)	26 (0%)	C	-	-	61 (0%)	-	Positive	Submit comment
Kurth, 1993	USA (Women)	CL	1 (detail)	20 (100%)	C	-	-	60 (100%)	-	Positive	Submit comment
Mellick, 1999a	Australia (Men)	CL	2 (detail)	124 (0%)	C	-	-	175 (0%)	-	Positive	Submit comment
Mellick, 1999a	Australia (Women)	CL	2 (detail)	80 (100%)	C	-	-	110 (100%)	-	Positive	Submit comment
Mellick, 1999b	Overlaps with Mellick, 1999a (Men)	CL	1 (detail)	124 (0%)	C	-	-	175 (0%)	-	n.a.	Submit comment
Mellick, 1999b	Overlaps with Mellick, 1999a (Women)	CL	1 (detail)	80 (100%)	C	-	-	110 (100%)	-	n.a.	Submit comment
Pankratz, 2008	USA (PROGENI, GenePD)-Men	CL	2 (detail)	537 (0%)	C	-	-	346 (0%)	-	Negative	Submit comment
Pankratz, 2008	USA (PROGENI, GenePD)-Women	CL	2 (detail)	363 (100%)	C	-	-	516 (100%)	-	Negative	Submit comment
Parsian, 2004	USA (Men)	CL	1 (detail)	169 (0%)	C	-	-	116 (0%)	-	Positive	Submit comment
Parsian, 2004	USA (Women)	CL	1 (detail)	91 (100%)	C	-	-	64 (100%)	-	Positive	Submit comment
Plante-Bordeneuve, 1997	France & UK (Men)	CL	1 (detail)	27 (0%)	C	-	-	27 (0%)	-	Negative	Submit comment
Plante-Bordeneuve, 1997	France & UK (Women)	CL	1 (detail)	33 (100%)	C	-	-	33 (100%)	-	Negative	Submit comment
Simon-Sanchez, 2009	USA (GWAS)-Men	CL,PO	2 (detail)	560 (0%)	C	-	-	336 (0%)	-	Negative
Simon-Sanchez, 2009	USA, Germany (GWAS)-Women	CL,PO	2 (detail)	687 (100%)	C	-	-	2056 (100%)	-	Negative
Simon-Sanchez, 2009	Germany (GWAS)-Men	CL,PO	2 (detail)	-	C	-	-	-	-	Negative
Takehashi, 2002	USA (Men)	CL	1 (detail)	37 (0%)	N	-	-	35 (0%)	-	Negative	Submit comment
Takehashi, 2002	USA (Women)	CL	1 (detail)	10 (100%)	N	-	-	32 (100%)	-	Negative	Submit comment
Asian
Chan, 2003	China (Men)	CL	1 (detail)	-	C	-	-	-	-	Positive	Submit comment
Chan, 2003	China (Women)	CL	1 (detail)	-	C	-	-	-	-	Positive	Submit comment
Hwang, 1997	Taiwan (Men)	CL	1 (detail)	41 (0%)	C	-	-	60 (0%)	-	Negative	Submit comment
Hwang, 1997	Taiwan (Women)	CL	1 (detail)	24 (100%)	C	-	-	48 (100%)	-	Negative	Submit comment
Mellick, 2000	Overlaps with Chan, 2003 (Men)	CL	1 (detail)	90 (0%)	C	-	-	99 (0%)	-	n.a.	Submit comment
Mellick, 2000	Overlaps with Chan, 2003 (Women)	CL	1 (detail)	86 (100%)	C	-	-	104 (100%)	-	n.a.	Submit comment
Morimoto, 1995	Japan (Men)	CL	1 (detail)	20 (0%)	C	-	-	36 (0%)	-	Negative	Submit comment
Morimoto, 1995	Japan (Women)	CL	1 (detail)	34 (100%)	C	-	-	20 (100%)	-	Negative	Submit comment
Nakatome, 1998	Japan (Men)	CL	1 (detail)	38 (0%)	C	-	-	102 (0%)	-	Negative	Submit comment
Nakatome, 1998	Japan (Women)	CL	1 (detail)	30 (100%)	C	-	-	126 (100%)	-	Negative	Submit comment
Nanko, 1996	Japan (Men)	CL	1 (detail)	36 (0%)	C	-	-	35 (0%)	-	Negative	Submit comment
Nanko, 1996	Japan (Women)	CL	1 (detail)	35 (100%)	C	-	-	35 (100%)	-	Negative	Submit comment
Tan, 2003	Singapore (Men)	CL	1 (detail)	145 (0%)	C	-	-	142 (0%)	-	Negative	Submit comment
Tan, 2003	Singapore (Women)	CL	1 (detail)	85 (100%)	C	-	-	99 (100%)	-	Negative	Submit comment
Wu, 2001	Taiwan (Men)	CL	1 (detail)	162 (0%)	C	-	-	145 (0%)	-	Positive	Submit comment
Wu, 2001	Taiwan (Women)	CL	1 (detail)	62 (100%)	C	-	-	52 (100%)	-	Positive	Submit comment
Other/Mixed
Lynch, 2003	USA (Men)	CL	1 (detail)	71 (0%)	C	-	-	30 (0%)	-	Negative	Submit comment
Lynch, 2003	USA (Women)	CL	1 (detail)	29 (100%)	C	-	-	36 (100%)	-	Negative	Submit comment
Punia, 2010	India (Men)	CL	1 (detail)	241 (0%)	C	-	50.6 + 11.9 (-)	249 (0%)	57.3 + 9.9 (-)	Negative
Punia, 2010	India (Women)	CL	1 (detail)	98 (100%)	C	-	50.6 + 11.9 (-)	95 (100%)	57.3 + 9.9 (-)	Negative
Singh, 2008	India (Men)	CL	1 (detail)	54 (0%)	C	-	-	77 (0%)	-	Positive	Submit comment
Singh, 2008	India (Women)	CL	1 (detail)	16 (100%)	C	-	-	23 (100%)	-	Positive	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Gao, 2008	USA (Men)	6 (detail)	736	-	C	-	-	-	-	Negative	Submit comment
Gao, 2008	USA (Women)	6 (detail)	736	-	C	-	-	-	-	Positive	Submit comment
Kang, 2006	Overlaps with Gao, 2008 (Men)	7 (detail)	644	-	C	58.1 + 12.7 (-)	-	-	-	Negative	Submit comment
Kang, 2006	Overlaps with Gao, 2008 (Women)	7 (detail)	644	-	C	57.4 + 13.9 (-)	-	-	-	Positive	Submit comment
Maraganore, 2005	USA (Men)	1 (detail)	443	271 (0%)	C	-	-	214 (0%)	-	Negative	Submit comment
Maraganore, 2005	USA (Women)	1 (detail)	443	172 (100%)	C	-	-	229 (100%)	-	Negative	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.