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Gene overview of all published PD-association studies for APOE

Gene:

APOE (AD2; MGC1571; apoprotein)

View on AlzGene View on MSGene View on SZGene

Protein:

apolipoprotein E (Alzheimer disease 2)

Chromosome:

19 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 8 September 2010

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Ballering, 1997	Overlaps with Ghebremedhin, 2006	CL	3 (detail)	50 (-)	M	-	-	107 (-)	-	n.a.	Submit comment
Benjamin, 1994	UK	CL	3 (detail)	23 (-)	-	-	-	55 (-)	-	Negative	Submit comment
Blazquez, 2006	Spain	CL	3 (detail)	276 (41%)	C	64.2 + 11.3 (-)	71.1 + 10.2 (-)	212 (48%)	70.9 + 8 (-)	Positive	Submit comment
Bon, 1999	Overlaps with Ghebremedhin, 2006	CL	3 (detail)	50 (-)	N	-	-	96 (-)	-	n.a.	Submit comment
Buchanan, 2006	Australia	CL	3 (detail)	422 (43%)	C	59.9 + 10.4 (-)	66.9 + 9.8 (-)	387 (71%)	64.1 + 10.8 (-)	Positive	Submit comment
Cramer, 2009	USA	CL	3 (detail)	53 (36%)	C	-	65 + 10 (-)	54 (-)	55 + 15 (-)	Negative
Eerola, 2002	Finland	CL	3 (detail)	147 (41%)	C	-	67.2 (38-88)	137 (64%)	65.8 (37-87)	Negative	Submit comment
Egensperger, 1996	Overlaps with Grasbon-Frodl, 1999	CL	3 (detail)	20 (-)	M	-	76 + 6.2 (-)	54 (-)	71.2 + 9.5 (-)	n.a.	Submit comment
Egensperger, 1997	Overlaps with Grasbon-Frodl, 1999	CL	3 (detail)	23 (35%)	M	-	75.5 (-)	100 (54%)	74.3 (-)	n.a.
Engelborghs, 2003	Belgium	CL	3 (detail)	30 (43%)	C	68.5 + 7.7 (-)	75.4 + 6.7 (59-90)	189 (54%)	58.8 + 16.9 (19-95)	Negative	Submit comment
Ezquerra, 2008	Spain	CL	3 (detail)	138 (42%)	C	-	56 + 8.4 (-)	91 (56%)	67 + 9.2 (-)	Negative	Submit comment
Ferrarese, 2001	Italy	CL	3 (detail)	38 (-)	C	-	-	28 (-)	-	Negative
French Study Group, 1997	France	CL	3 (detail)	103 (46%)	C	57 (-)	65 (-)	387 (44%)	67 + 9 (-)	Positive	Submit comment
Fung, 2006	Overlaps with Simon-Sanchez, 2009 (USA)	CL	1 (detail)	267 (-)	C	-	-	270 (-)	68 (55-88)	n.a.	Submit comment
Ghebremedhin, 2006	Netherlands	CL	3 (detail)	108 (43%)	M	65.8 (-)	75.1 + 6.9 (55-89)	108 (43%)	75.1 + 6.9 (55-89)	Positive	Submit comment
Grasbon-Frodl, 1999	Germany	CL	3 (detail)	62 (53%)	M	-	70 (-)	53 (58%)	71 (-)	Negative	Submit comment
Hardy, 1994	UK	CL	3 (detail)	24 (-)	N	-	75 + 7 (-)	46 (-)	-	Negative	Submit comment
Harhangi, 2000	Netherlands	PO	3 (detail)	81 (63%)	C	-	75.8 + 7.8 (-)	4805 (55%)	69 + 8.6 (-)	Positive	Submit comment
Harrington, 1994	UK & Belgium	CL	3 (detail)	51 (49%)	N	-	77.7 + 7.1 (64-94)	58 (52%)	78.1 + 7.7 (60-91)	Negative	Submit comment
Helisalmi, 1996	Finland	CL	3 (detail)	15 (47%)	C	-	71 + 6 (-)	60 (47%)	69 + 8 (-)	Negative	Submit comment
Ibarreta, 1995	Spain	CL	3 (detail)	64 (-)	C	-	65.8 + 16 (44-90)	42 (-)	67.7 + 1.9 (52-90)	Negative	Submit comment
Khan, 2001	UK	CL	3 (detail)	305 (45%)	M	57 (-)	61 + 6 (-)	330 (47%)	63 + 7 (-)	Negative	Submit comment
Koller, 1995	USA	CL	3 (detail)	61 (38%)	C	-	67.4 + 7.9 (-)	78 (53%)	69.9 + 6.5 (-)	Negative	Submit comment
Kruger, 1999	Overlaps with Simon-Sanchez, 2009 (Germany)	CL	4 (detail)	236 (44%)	C	-	66.5 + 11 (-)	200 (-)	-	n.a.	Submit comment
Kruger, 2000	Overlaps with Schulte, 2003	CL	3 (detail)	191 (-)	C	-	-	293 (-)	-	n.a.	Submit comment
Kurz, 2009	Norway	CL,PO	3 (detail)	95 (-)	M	-	-	73 (-)	-	Positive	Submit comment
Maraganore, 2000	USA	CL	3 (detail)	139 (35%)	C	62 (31-82)	69 (39-91)	113 (65%)	72 (37-90)	Negative	Submit comment
Martinoli, 1995	Canada	CL	3 (detail)	10 (-)	N	-	69 (24-86)	243 (-)	-	Negative	Submit comment
Mattila, 1998	Finland	CL	3 (detail)	11 (45%)	M	-	71.9 + 6.8 (-)	59 (44%)	76 (-)	Negative	Submit comment
McCulloch, 2008	USA (Washington)	CL	3 (detail)	391 (26%)	C	-	67.3 (32-95)	293 (58%)	67.3 (30-93)	Positive	Submit comment
McCulloch, 2008	USA (Oregon)	CL	3 (detail)	172 (38%)	C	-	65.9 (39-87)	96 (55%)	67.8 (21-83)	Positive	Submit comment
McCulloch, 2008	USA (New York)	CL	3 (detail)	253 (35%)	C	-	68.1 (40-95)	214 (66%)	64.6 (34-94)	Positive	Submit comment
McCulloch, 2008	USA (Georgia)	CL	3 (detail)	116 (37%)	C	-	67.3 (40-97)	61 (67%)	68.5 (51-84)	Positive	Submit comment
Morris, 1996	Overlaps with Benjamin, 1994	CL	3 (detail)	11 (-)	M	-	-	99 (-)	-	n.a.	Submit comment
Oliveri, 1999	Italy	CL	4 (detail)	126 (43%)	C	58 + 10.4 (-)	65.8 + 9 (43-87)	119 (52%)	66.3 + 8.5 (50-92)	Negative	Submit comment
Pankratz, 2008	USA (PROGENI, GenePD)	CL	1 (detail)	857 (41%)	C	61.9 + 10.8 (-)	-	867 (60%)	54.8 + 13.1 (-)	Negative	Submit comment
Papapetropoulos, 2007	USA	CL	3 (detail)	118 (28%)	N	-	77 + 7.9 (-)	91 (53%)	79.1 + 12.8 (-)	Positive	Submit comment
Parsian, 2002	USA	CL	3 (detail)	285 (35%)	C	60 (22-82)	68 (-)	96 (35%)	62 + 14 (-)	Negative	Submit comment
Payami, 2009	Re-analysis of McCulloch, 2008	CL	3 (detail)	-	-	-	-	-	-	n.a.
Poduslo, 1995	USA	CL	3 (detail)	54 (-)	C	-	74.1 + 7.5 (-)	77 (-)	71.9 + 7.4 (-)	Negative	Submit comment
Rubinsztein, 1994	UK	CL	3 (detail)	34 (24%)	C	-	57 (-)	34 (-)	-	Negative	Submit comment
Schulte, 2003	Germany	CL	3 (detail)	457 (46%)	C	-	67.5 + 10.5 (-)	340 (48%)	72 + 4.3 (-)	Positive	Submit comment
Simon-Sanchez, 2009	USA, Germany (GWAS)	CL,PO	1 (detail)	1745 (45%)	C	55.8 (7-98)	-	4047 (50%)	-	Negative
St.Clair, 1997	UK	CL	3 (detail)	58 (33%)	M	-	78 (69-90)	47 (38%)	78 (67-91)	Negative	Submit comment
Troster, 2006	USA	CL	3 (detail)	62 (29%)	C	62.7 (-)	68.6 (-)	146 (51%)	71.5 + 7.2 (-)	Positive	Submit comment
Whitehead, 1996	Ireland	PO	3 (detail)	189 (35%)	C	45.6 + 7.6 (-)	56.9 + 6.6 (-)	162 (38%)	58 + 7.1 (-)	Negative	Submit comment
Williams-Gray, 2009	UK	CL,PO	3 (detail)	528 (40%)	C	62.5 + 11.8 (-)	-	512 (52%)	-	Negative	Submit comment
Asian
Arai, 1994	Overlaps with Higuchi, 2000	CL	3 (detail)	49 (-)	-	-	-	24 (-)	-	n.a.	Submit comment
Galasko, 2002	USA (Guam)	CL	3 (detail)	11 (55%)	C	63.3 + 3.3 (-)	68.4 + 9.8 (-)	403 (-)	-	Negative	Submit comment
Higuchi, 2000	Japan	CL	3 (detail)	140 (56%)	C	-	65.5 + 9.5 (-)	382 (69%)	74 + 5.6 (-)	Negative	Submit comment
Ryu, 2010 * Recently Added *	Korea	CL	1 (detail)	234 (71%)	C	66.3 + 9.5 (-)	71.1 + 8.2 (-)	192 (49%)	72.2 + 4.9 (-)	Negative
Tang, 2002	China	CL	3 (detail)	68 (49%)	C	64.4 + 10.3 (-)	65.6 + 5.4 (43-76)	160 (53%)	55.8 + 15.4 (33-95)	Positive	Submit comment
Hispanic
Gallegos-Arreola, 2009	Mexico	CL	3 (detail)	105 (40%)	C	-	63 + 9 (-)	107 (56%)	50 + 14 (-)	Positive
Lopez, 2007	Mexico	CL	3 (detail)	229 (40%)	C	54.1 + 12.3 (-)	62.2 + 12.8 (-)	229 (40%)	63.9 + 11.2 (-)	Positive	Submit comment
Other/Mixed
Clark, 2003	USA	CO	1 (detail)	84 (56%)	C	-	67.8 + 10.3 (-)	458 (64%)	75.7 + 6 (-)	n.a.	Submit comment
Inzelberg, 1998	Israel	CL	1 (detail)	78 (22%)	C	-	72 + 12 (-)	93 (59%)	70 + 13 (-)	Trend
Marder, 1994	USA	CL	3 (detail)	57 (-)	C	-	71.2 (-)	44 (61%)	72.6 (-)	Negative	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Li, 2004	USA & Australia	3 (detail)	658	972 (-)	C	-	-	873 (-)	-	Positive	Submit comment
Martinez, 2005	USA & Europe	3 (detail)		387 (-)	U	-	-	257 (-)	-	Positive	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.