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Gene overview of all published PD-association studies for FGF20

Gene:

FGF20

View on SZGene

Protein:

fibroblast growth factor 20

Chromosome:

8 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 22 June 2010

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Clarimon, 2005	Greece	CL	4 (detail)	151 (46%)	C	-	70.3 (40-95)	186 (-)	-	Negative	Submit comment
Clarimon, 2005	Finland	CL	4 (detail)	144 (41%)	C	-	67.2 (38-88)	135 (64%)	65.8 (37-80)	Trend	Submit comment
De Mena, 2010	Spain	CL	1 (detail)	512 (45%)	C	-	-	258 (62%)	73 + 11 (24-97)	Negative
Fung, 2006	USA (NINDS)	CL	1 (detail)	267 (-)	C	-	-	270 (-)	68 (55-88)	Negative	Submit comment
Wider, 2009	Ireland	CL	4 (detail)	174 (61%)	C	49 + 11 (18-77)	61 + 12 (33-90)	174 (61%)	61 + 12 (33-90)	Negative	Submit comment
Wider, 2009	USA (I)	CL	4 (detail)	420 (46%)	C	62 + 12 (16-85)	72 + 11 (29-91)	420 (46%)	71 + 11 (32-92)	Negative	Submit comment
Wider, 2009	Norway	CL	4 (detail)	515 (40%)	C	59 + 11 (25-88)	72 + 11 (30-99)	1138 (53%)	73 + 11 (43-106)	Negative	Submit comment
Wider, 2009	USA (II)	CL	4 (detail)	153 (33%)	N	63 + 10 (40-86)	78 + 7 (60-93)	149 (48%)	75 + 16 (27-102)	Negative	Submit comment
Asian
Satake, 2007	Japan	CL	3 (detail)	1388 (54%)	C	57.7 + 11.1 (-)	65.7 + 9.8 (-)	1891 (48%)	48.5 + 17.6 (-)	Positive	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Gao, 2008	USA	8 (detail)	736	-	C	-	-	-	-	Positive	Submit comment
Van der Walt, 2004	Overlaps with Gao, 2008	5 (detail)	644	-	C	-	-	-	-	n.a.	Submit comment
Wang, 2008	Overlaps with Gao, 2008	8 (detail)	729	1089 (-)	C	-	-	1165 (-)	-	n.a.	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.