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Gene overview of all published PD-association studies for SLC6A3

Gene:

SLC6A3 (DAT; DAT1)

View on AlzGene View on SZGene

Protein:

solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 (dopamine transporter)

Chromosome:

5 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 29 June 2010

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
De Palma, 2010	Overlaps with Dick, 2007	CL	1 (detail)	767 (44%)	C	-	69.8 + 9.2 (-)	1989 (47%)	69.8 + 10 (-)	n.a.
Dick, 2007	Europe	CL	1 (detail)	767 (44%)	C	61.6 + 9.9 (-)	69.8 + 9.2 (-)	1989 (47%)	69.8 + 10 (-)	Negative	Submit comment
Fung, 2006	Overlaps with Simon-Sanchez, 2009 (USA)	CL	3 (detail)	267 (-)	C	-	-	270 (-)	68 (55-88)	Negative	Submit comment
Goudreau, 2002	USA	CL,PO	1 (detail)	319 (38%)	C	64 (31-91)	70 (33-99)	196 (62%)	72 (37-94)	Negative	Submit comment
Kelada, 2005	Overlaps with Kelada, 2006	CL	7 (detail)	261 (35%)	C	-	66.7 + 9.9 (37-81)	376 (39%)	69.1 + 8.6 (36-88)	n.a.	Submit comment
Kelada, 2006	USA	CL	7 (detail)	293 (37%)	C	-	66.4 (29-88)	395 (38%)	69.3 (45-85)	Positive	Submit comment
Le Couteur, 1997	Australia	CL	1 (detail)	100 (40%)	C	63 + 12 (-)	70 + 10 (-)	200 (39%)	70 + 12 (-)	Positive	Submit comment
Mercier, 1999	France	CL	1 (detail)	75 (40%)	C	62 + 9 (25-88)	71 + 9 (-)	78 (40%)	70 + 11 (-)	Negative
Nicholl, 1999	UK	CL	1 (detail)	206 (41%)	C	-	64.4 (31-83)	206 (41%)	63.9 (17-94)	Negative	Submit comment
Pankratz, 2008	USA (PROGENI, GenePD)	CL	2 (detail)	857 (41%)	C	61.9 + 10.8 (-)	-	867 (60%)	54.8 + 13.1 (-)	Negative	Submit comment
Plante-Bordeneuve, 1997	France & UK	CL	1 (detail)	78 (-)	C	-	-	60 (-)	-	Negative	Submit comment
Ritz, 2009	USA	PO	3 (detail)	264 (-)	C	-	-	268 (-)	-	Positive
Simon-Sanchez, 2009	USA, Germany (GWAS)	CL,PO	2 (detail)	1745 (45%)	C	55.8 (7-98)	-	4047 (50%)	-	Negative
Asian
Higuchi, 1995	Japan	CL	1 (detail)	70 (-)	C	-	67.1 + 9.8 (-)	70 (-)	67.1 + 10 (-)	Negative	Submit comment
Kim, 2000	Korea	CL	1 (detail)	116 (61%)	C	-	58.6 + 11.2 (-)	128 (63%)	60.2 + 10.5 (-)	Positive	Submit comment
Kimura, 2001	Overlaps with Higuchi, 1995	CL	2 (detail)	204 (-)	C	-	65.2 + 9.4 (-)	300 (-)	65.2 + 17 (-)	Negative	Submit comment
Leighton, 1997	China	CL	1 (detail)	203 (48%)	C	-	70 + 10 (-)	230 (50%)	69 + 11 (-)	Negative	Submit comment
Lin, 2002	Taiwan	CL	1 (detail)	102 (26%)	C	-	67.9 + 9.8 (-)	174 (30%)	68.9 + 8.9 (-)	Negative	Submit comment
Lin, 2003	Taiwan	CL	1 (detail)	193 (49%)	C	63.5 + 12 (-)	68.8 + 9.4 (-)	254 (49%)	68.7 + 8.1 (-)	Positive	Submit comment
Morino, 2000	Japan	CL	2 (detail)	172 (61%)	C	62.7 + 8.1 (-)	-	132 (50%)	63.7 + 7.3 (-)	Positive	Submit comment
Nishimura, 2002	Japan	CL	1 (detail)	236 (60%)	C	-	65.5 + 9.7 (35-86)	220 (60%)	63.2 + 9.1 (40-82)	Positive	Submit comment
Other/Mixed
Juyal, 2006	India (North)	CL	1 (detail)	340 (29%)	C	-	50.6 + 11.9 (20-78)	344 (28%)	57.3 + 9.9 (-)	Negative	Submit comment
Juyal, 2006	India (South)	CL	1 (detail)	147 (35%)	C	-	47.7 + 13.8 (-)	130 (35%)	58.2 + 12.3 (-)	Trend	Submit comment
Lynch, 2003	USA	CL	1 (detail)	100 (29%)	C	54 (37-80)	60.8 (38-84)	66 (55%)	46.5 (18-83)	Negative	Submit comment
Ritz, 2009	USA	PO	3 (detail)	60 (-)	C	-	-	66 (-)	-	Positive
Singh, 2008	India	CL	1 (detail)	70 (23%)	C	-	58.7 + 10.7 (22-82)	100 (23%)	53.8 + 9.6 (22-74)	Negative	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.