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PDGene - Gene overview of all published PD-association studies for GSTO1
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 Gene: GSTO1  (P28; GSTTLp28; DKFZp686H13163)  Entrez Gene    View on AlzGene   View on SZGene
 Protein: glutathione-S-transferase omega 1  (glutathione transferase omega; glutathione-S-transferase like; glutathione transferase omega 1; glutathione S-transferase omega 1-1)  ProteinLink
 Chromosome: 10   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 2 October 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      PD Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Fung, 2006
USA (NINDS) CL  1  (detail)  267
(-)
C--270
(-)
68
(55-88)
Negative
Maraganore, 2005
USA CL  1  (detail)  332
(42%)
C63
(36-88)
68
(42-90)
332
(42%)
67
(42-91)
Negative
Pankratz, 2008
USA (PROGENI, GenePD) CL  3  (detail)  857
(41%)
C61.9 + 10.8
(-)
-867
(60%)
54.8 + 13.1
(-)
Negative
Simon-Sanchez, 2009
USA (NINDS-GWAS) CL  3  (detail)  931
(40%)
C--790
(58%)
-Negative
Wahner, 2006
USA PO  1  (detail)  235
(46%)
C-69.5
(-)
220
(47%)
67.1
(-)
Positive
Whitbread, 2004
Australia CL  2  (detail)  342
(-)
C--337
(-)
-Negative
 Asian
Kiyohara, 2010
Japan CL  2  (detail)  238
(59%)
C-68.5
(64-74)
370
(62%)
66.6
(62-72)
Negative
Mizuta, 2006
Japan CL  2  (detail)  190
(-)
C--190
(-)
-Negative
 Other/Mixed
Wahner, 2006
USA PO  1  (detail)  54
(46%)
C--50
(54%)
-n.a.
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Li, 2003
USA  1  (detail)  298635
(-)
M59 + 13
(12-90)
-727
(-)
-Positive
Maraganore, 2005
USA  2  (detail)  443443
(39%)
C61
(31-94)
68
(33-96)
443
(52%)
66
(29-90)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis ->  "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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Studies: 881
Genes: 915
Polymorphisms: 3446
Meta-analyses: 889
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