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Gene overview of all published PD-association studies for MTHFR

Gene:

MTHFR

View on AlzGene View on MSGene View on SZGene

Protein:

5,10-methylenetetrahydrofolate reductase (NADPH) (Methylenetetrahydrofolate reductase; methylenetetrahydrofolate reductase intermediate form)

Chromosome:

1 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 29 June 2010

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Caccamo, 2007	Italy	CL	2 (detail)	49 (55%)	C	58.4 + 7.6 (-)	64.2 + 7.5 (-)	86 (53%)	64.1 + 7.1 (-)	Negative	Submit comment
De Lau, 2005	Netherlands	PO	1 (detail)	65 (54%)	C	-	74.9 + 7.2 (-)	5855 (58%)	68.7 + 8.6 (-)	Positive	Submit comment
Dorszewska, 2007	Poland	CL	3 (detail)	98 (38%)	C	-	60.8 + 10.7 (34-81)	50 (68%)	44.6 + 16.2 (22-76)	Negative	Submit comment
Fung, 2006	Overlaps with Simon-Sanchez, 2009 (USA)	CL	2 (detail)	267 (-)	C	-	-	270 (-)	68 (55-88)	Negative	Submit comment
Harmon, 1997	Ireland	CL	1 (detail)	188 (-)	C	-	-	184 (-)	-	Negative	Submit comment
Kuhn, 2001	Germany	CL	1 (detail)	82 (30%)	C	-	63.1 + 10.7 (-)	39 (36%)	61.5 + 10.8 (-)	n.a.
Pankratz, 2008	USA (PROGENI, GenePD)	CL	2 (detail)	857 (41%)	C	61.9 + 10.8 (-)	-	867 (60%)	54.8 + 13.1 (-)	Negative	Submit comment
Religa, 2006	Poland	CL	1 (detail)	114 (-)	C	-	69.9 (-)	100 (-)	71.2 + 6 (-)	Negative	Submit comment
Simon-Sanchez, 2009	USA, Germany (GWAS)	CL,PO	1 (detail)	1745 (45%)	C	55.8 (7-98)	-	4047 (50%)	-	Negative
Todorovic, 2006	Serbia	CL	1 (detail)	113 (44%)	C	-	-	53 (36%)	60.8 + 13.1 (37-83)	Positive	Submit comment
Wullner, 2005	Germany	CL	2 (detail)	342 (29%)	C	-	59 + 9 (-)	342 (50%)	58 + 16 (-)	Positive	Submit comment
Asian
Lin, 2007	Taiwan	CL	1 (detail)	94 (47%)	C	61.2 + 10 (32-90)	69.5 + 11 (-)	146 (47%)	68.5 + 6.1 (-)	Positive	Submit comment
Mizuta, 2006	Overlaps with Momose, 2002	CL	1 (detail)	190 (-)	C	-	-	190 (-)	-	n.a.	Submit comment
Momose, 2002	Japan	CL	1 (detail)	232 (51%)	C	54.1 + 10.5 (24-80)	-	249 (49%)	-	Negative	Submit comment
Toda, 2003	Overlaps with Momose, 2002	CL	1 (detail)	232 (51%)	C	54.1 + 10.5 (24-80)	-	249 (49%)	-	n.a.	Submit comment
Yasui, 2000	Japan	CL	1 (detail)	90 (66%)	C	-	64.8 + 12.6 (-)	50 (74%)	67.8 + 12.2 (-)	Positive	Submit comment
Yuan, 2009	Taiwan	CL	2 (detail)	76 (63%)	C	-	71.3 + 9.8 (-)	110 (66%)	69.9 + 8.4 (-)	n.a.

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.