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Gene overview of all published PD-association studies for GBA
Back Search Methods Disclaimer Credits
 Gene: GBA  (GCB; GBA1; GLUC)  Entrez Gene    View on AlzGene
 Protein: glucocerebrosidase  (glucocerebrosidase (alt.); lysosomal glucocerebrosidase; D-glucosyl-N-acylsphingosine glucohydrolase)  ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 17 December 2012
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      PD Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result
 Caucasian
Aharon-Peretz, 2004
 Israel CL  1  (detail)  99
(44%)		C--1543
(-)		-Trend
Bras, 2007
 Overlaps with
Sidransky, 2009 (Portugal)		 CL  2  (detail)  230
(-)		C--430
(-)		-Positive
Clark, 2005
 Overlaps with
Clark, 2007		 CL  1  (detail)  160
(38%)		C59 + 12.4
(-)		66.5 + 10.5
(-)		92
(41%)		69.6 + 9.6
(-)		n.a.
Clark, 2007
 USA CL  2  (detail)  278
(37%)		C-65.6 + 11.3
(-)		179
(44%)		64.9 + 11.3
(-)		Positive
De Marco, 2008
 Italy CL  1  (detail)  395
(38%)		C60.3 + 10.2
(-)		66.4 + 9.1
(-)		483
(63%)		56.9 + 17.3
(-)		Positive
Do, 2011
 USA (23andMe-GWAS) CL  1  (detail)  3426
(40%)		M57.4 + 10.7
(-)		64.3 + 10.6
(-)		29624
(42%)		48.2 + 16
(-)		Positive
Emelyanov, 2011
 Russia CL  1  (detail)  330
(-)		C-63.8 + 9.8
(-)		240
(-)		67.7 + 8.8
(-)		Positive
Fung, 2006
 Overlaps with
Simon-Sanchez, 2009 (USA)		 CL  2  (detail)  267
(-)		C--270
(-)		68
(55-88)		n.a.
Gan-Or, 2008
 Israel CL  1  (detail)  420
(38%)		C59.4 + 11.3
(21-94)		67.9 + 10.2
(41-96)		4138
(-)		-Positive
Lesage, 2010
 France CL  2  (detail)  1130
(-)		C--391
(-)		-Positive
Lwin, 2004
 USA CL  2  (detail)  56
(-)		N-76
(54-99)		44
(-)		70
(-)		Trend
Mata, 2008
 Overlaps with
Sidransky, 2009 (USA)		 CL  1  (detail)  721
(25%)		C58.2 + 12
(-)		67.1 + 11
(-)		554
(64%)		65.3 + 12.5
(-)		n.a.
Moraitou, 2011
 Greece CL  1  (detail)  205
(52%)		C-64.2
(37-88)		206
(-)		66.8 + 114
(40-95)		Positive
Neumann, 2009
 UK CL  1  (detail)  790
(22%)		M58.7 + 12.3
(-)		-257
(-)		53
(-)		Positive
Nichols, 2008
 Overlaps with
Pankratz, 2008 (USA-PROGENI)		 CL  2  (detail)  450
(-)		C--359
(56%)		70.3
(55-92)		Positive
Pankratz, 2008
 USA (PROGENI, GenePD) CL  3  (detail)  857
(41%)		C61.9 + 10.8
(-)		-867
(60%)		54.8 + 13.1
(-)		Negative
Sato, 2005
 Canada CL  1  (detail)  88
(41%)		C41.2 + 12.9
(14-72)		58.4 + 13.7
(-)		122
(59%)		65 + 8.6
(47-80)		Positive
Sidransky, 2009
 Overlaps with
Toft, 2006 (Norway)		 CL  1  (detail)  311
(40%)		C--473
(44%)		64.1
(-)		n.a.
Sidransky, 2009
 Overlaps with
Sato, 2005 (Canada)		 CL  1  (detail)  88
(42%)		C-55
(-)		96
(72%)		69.6
(-)		n.a.
Sidransky, 2009
 Overlaps with
De Marco, 2008 (Italy)		 CL  1  (detail)  395
(38%)		C-66.5
(-)		483
(63%)		56.9
(-)		n.a.
Sidransky, 2009
 Portugal CL  2  (detail)  231
(52%)		C-65.3
(-)		482
(-)		65.5
(-)		n.a.
Sidransky, 2009
 Germany (Tuebingen) CL  1  (detail)  377
(41%)		C-64.8
(-)		325
(41%)		58.3
(-)		n.a.
Sidransky, 2009
 Germany (Rostock) CL  2  (detail)  298
(36%)		C-64.3
(-)		212
(50%)		74.5
(-)		Trend
Sidransky, 2009
 France CL  1  (detail)  297
(38%)		C-57.8
(-)		251
(43%)		57.8
(-)		Positive
Simon-Sanchez, 2009
 USA, Germany (GWAS) CL,PO  2  (detail)  1745
(45%)		C55.8
(7-98)		-4047
(50%)		-Negative
Simon-Sanchez, 2009
 USA (NINDS-GWAS) CL  1  (detail)  931
(40%)		C--790
(58%)		-Negative
Sutherland, 2009
 Australia CL  2  (detail)  331
(51%)		C60.1 + 10.6
(-)		70.3 + 8.7
(-)		296
(51%)		70.5 + 8.9
(-)		Negative
Toft, 2006
 Norway CL  1  (detail)  311
(40%)		C59 + 10.9
(31-88)		-474
(-)		60.5
(-)		Negative
 Asian
Hu, 2010
 China CL  1  (detail)  328
(46%)		C52.6 + 11.8
(-)		-300
(-)		-Trend
Sidransky, 2009
 Taiwan CL  2  (detail)  559
(46%)		C-69.1
(-)		377
(47%)		60.5
(-)		Negative
Sidransky, 2009
 Singapore CL  1  (detail)  329
(48%)		C-70.3
(-)		201
(51%)		64.2
(-)		Negative
Sidransky, 2009
 Japan CL  2  (detail)  534
(47%)		C-65.3
(-)		546
(46%)		44.8
(-)		Negative
Sun, 2010
 China CL  1  (detail)  402
(40%)		C54.7 + 12.1
(8-79)		-413
(-)		-n.a.
 Other/Mixed
Eblan, 2006
 Venezuela CL  1  (detail)  33
(-)		C36
(24-50)		36
(-)		31
(-)		-Positive
Lesage, 2011
 Algeria, Morocco, Tunisia, Libya CL  3  (detail)  194
(48%)		C50.9 + 12.9
(12-78)		58.8 + 13.3
(14-83)		177
(61%)		49.5 + 14.5
(19-84)		Positive
Nishioka, 2009
 Tunisia CL  2  (detail)  240
(52%)		C57.1 + 13
(-)		-372
(49%)		58.3 + 11
(-)		Negative
Santos, 2010
 Brazil CL  1  (detail)  110
(33%)		C41.2 + 8
(-)		52.6 + 10.8
(-)		155
(47%)		62.7 + 9.4
(-)		Positive
Sidransky, 2009
 USA (Seattle) CL  2  (detail)  811
(25%)		C-66.9
(-)		518
(63%)		65.2
(-)		Positive
Sidransky, 2009
 Overlaps with
Gan-Or, 2008 (Israel)		 CL  1  (detail)  420
(38%)		C-68
(-)		321
(50%)		65.3
(-)		n.a.
Sidransky, 2009
 USA (NHGRI) CL  2  (detail)  539
(31%)		C-73.5
(-)		209
(52%)		67.6
(-)		Trend
Sidransky, 2009
 Overlaps with
Clark, 2007 (USA)		 CL  2  (detail)  275
(38%)		C-65.6
(-)		140
(48%)		62.8
(-)		n.a.
Sidransky, 2009
 Brazil CL  1  (detail)  65
(35%)		C-54.1
(-)		264
(36%)		54.4
(-)		n.a.
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result
 Caucasian
Lesage, 2010
 Overlaps with
Lesage, 2010 (CC)		  2  (detail)  21-C--50
(-)		-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis ->  "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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