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Gene overview of all published PD-association studies for LRRK2

Gene:

LRRK2 (PARK8; ROCO2)

View on AlzGene

Protein:

leucine-rich repeat kinase 2 (dardarin)

Chromosome:

12 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 8 September 2010

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Biskup, 2005	Overlaps with Simon-Sanchez, 2009 (Germany)	CL	97 (detail)	340 (42%)	C	52 (-)	-	680 (-)	-	Negative	Submit comment
Biskup, 2005	Overlaps with Simon-Sanchez, 2009 (Germany)	CL	6 (detail)	322 (-)	C	-	-	322 (-)	-	Negative	Submit comment
Clark, 2006	USA	CL	11 (detail)	504 (40%)	C	53.8 (-)	61.8 + 12.5 (-)	314 (43%)	66.5 + 11.4 (-)	Positive
Dupre, 2007	Canada	CL	6 (detail)	125 (29%)	C	55.3 (30-79)	-	95 (-)	-	Negative
Fung, 2006	Overlaps with Simon-Sanchez, 2009 (USA)	CL	59 (detail)	267 (-)	C	-	-	270 (-)	68 (55-88)	Negative	Submit comment
Lesage, 2009	Mixed	CL	1 (detail)	220 (-)	C	-	-	174 (-)	-	Negative
Lu, 2008	Netherlands	CL	1 (detail)	106 (-)	C	-	-	96 (-)	-	Positive	Submit comment
Maraganore, 2005	USA	CL	1 (detail)	332 (42%)	C	63 (36-88)	68 (42-90)	332 (42%)	67 (42-91)	Negative	Submit comment
Nuytemans, 2009	Belgium	CL	16 (detail)	310 (42%)	C	60.1 + 11.3 (-)	-	363 (47%)	67 + 10 (-)	n.a.
Ozelius, 2006	USA (Ashkenazi)	CL	5 (detail)	120 (-)	C	-	-	-	-	Positive
Paisan-Ruiz, 2005	Canada	CL	4 (detail)	121 (40%)	C	37.9 + 10.8 (14-65)	56.9 + 11.7 (33-83)	250 (59%)	73.3 + 8.5 (58-96)	Negative	Submit comment
Paisan-Ruiz, 2006	Finland	CL	36 (detail)	147 (41%)	C	-	67.2 (38-88)	136 (63%)	65.8 (37-87)	Negative	Submit comment
Paisan-Ruiz, 2006	Greece	CL	36 (detail)	217 (40%)	C	63.3 + 9.6 (30-88)	69.8 + 8.7 (44-95)	221 (44%)	68.3 + 12.8 (32-93)	Negative	Submit comment
Paisan-Ruiz, 2008	Overlaps with Simon-Sanchez, 2009 (USA)	CL	87 (detail)	272 (50%)	C	-	-	275 (52%)	68 (55-88)	Negative	Submit comment
Paisan-Ruiz, 2009	Re-analysis of Fung, 2006	CL	0	-	-	-	-	-	-	n.a.
Pankratz, 2008	USA (PROGENI, GenePD)	CL	53 (detail)	857 (41%)	C	61.9 + 10.8 (-)	-	867 (60%)	54.8 + 13.1 (-)	Negative	Submit comment
Patra, 2008	USA	CL	6 (detail)	575 (42%)	C	60.2 (22-82)	68 (-)	186 (61%)	62 + 14 (-)	Negative	Submit comment
Simon-Sanchez, 2009	USA, Germany, UK (Stage II)	CL,PO	1 (detail)	3452 (32%)	M	61.1 (-)	-	4756 (39%)	-	Positive
Simon-Sanchez, 2009	USA, Germany (GWAS)	CL,PO	48 (detail)	1745 (45%)	C	55.8 (7-98)	-	4047 (50%)	-	Positive
Sutherland, 2009	Australia	CL	24 (detail)	331 (51%)	C	60.1 + 10.6 (-)	70.3 + 8.7 (-)	296 (51%)	70.5 + 8.9 (-)	Trend	Submit comment
Toft, 2007a	Spain	CL	1 (detail)	205 (-)	C	-	66 + 13 (-)	205 (-)	-	Negative
Toft, 2007a	Norway	CL	1 (detail)	388 (-)	C	-	70 + 11 (-)	338 (-)	-	Negative
Toft, 2007a	Ireland	CL	1 (detail)	186 (-)	C	-	61 + 13 (-)	186 (-)	-	Negative
Toft, 2007b	Norway	CL	1 (detail)	433 (-)	C	58 + 11 (25-88)	71 + 11 (43-97)	587 (-)	69 + 12 (41-104)	Negative	Submit comment
African Descent
Ross, 2010 * Recently Added *	USA	CL	14 (detail)	22 (55%)	C	50.6 (27-65)	58.7 (40-72)	92 (73%)	41.9 (20-71)	Negative
Asian
An, 2008	Overlaps with Tan, 2010 (China)	CL	1 (detail)	600 (41%)	C	-	55.9 (20-85)	334 (46%)	53.6 + 13.8 (24-91)	n.a.	Submit comment
Chan, 2008	China	CL	1 (detail)	82 (46%)	C	56.9 (17-95)	63.8 (-)	31 (-)	70.4 + 9.2 (44-82)	Positive	Submit comment
Choi, 2008	Korea	CL	1 (detail)	72 (53%)	C	38.8 + 7 (13-50)	-	100 (-)	-	Positive	Submit comment
Di Fonzo, 2006	Taiwan	CL	2 (detail)	608 (40%)	C	54.9 + 11.9 (12-94)	66 + 12 (24-97)	373 (57%)	54.7 + 18.2 (11-87)	Positive	Submit comment
Farrer, 2007	Taiwan	CL	1 (detail)	410 (43%)	C	57.7 (-)	-	335 (-)	-	Positive	Submit comment
Funayama, 2007	Japan	CL	1 (detail)	448 (52%)	C	50.7 + 14.6 (5-89)	59.4 + 13.8 (15-93)	457 (47%)	43.8 + 16 (21-98)	Positive	Submit comment
Fung, 2006	Taiwan	CL	1 (detail)	305 (46%)	C	61.8 + 10.6 (30-91)	-	176 (46%)	59.6 + 9.6 (38-86)	Positive	Submit comment
Kim, 2009	South Korea	CL	2 (detail)	923 (56%)	C	54.8 + 10.9 (18-85)	63.7 + 9.9 (22-91)	422 (55%)	61.9 + 9.5 (37-85)	Positive
Li, 2007	China	CL	1 (detail)	235 (43%)	C	54.6 + 13.3 (14-88)	62.6 + 11.4 (15-88)	214 (43%)	52.9 + 11.7 (15-80)	Positive	Submit comment
Lu, 2008	Taiwan	CL	4 (detail)	834 (41%)	C	55.6 + 12.1 (12-94)	65.7 + 11.8 (24-97)	543 (59%)	51.9 + 18.4 (11-87)	Positive	Submit comment
Miyake, 2010 * Recently Added *	Japan	CL	1 (detail)	229 (62%)	C	-	68.4 + 8.7 (-)	358 (61%)	66.6 + 8.5 (-)	Positive
Pulkes, 2010	Thailand	CL	2 (detail)	154 (44%)	C	61.2 + 9.8 (-)	-	156 (-)	-	Positive
Ross, 2008	Overlaps with Tan, 2006 (Singapore)	CL	1 (detail)	250 (-)	C	-	-	250 (-)	-	n.a.	Submit comment
Ross, 2008	Taiwan (I)	CL	1 (detail)	484 (-)	C	-	-	341 (-)	-	Positive	Submit comment
Ross, 2008	Taiwan (II)	CL	1 (detail)	345 (-)	C	-	-	316 (-)	-	Positive	Submit comment
Ross, 2008	Japan	CL	1 (detail)	151 (-)	C	-	-	95 (-)	-	Negative	Submit comment
Satake, 2009	Japan (Replication-2)	CL	5 (detail)	321 (55%)	C	63.7 + 9.7 (-)	-	1614 (55%)	59.1 + 19.1 (-)	Positive
Satake, 2009	Japan (Replication-1)	CL	5 (detail)	612 (50%)	C	43 + 13.8 (20-80)	-	14139 (42%)	60.1 + 12.6 (-)	Positive
Satake, 2009	Japan (GWAS)	CL	5 (detail)	1078 (55%)	C	-	58.8 + 10.1 (22-88)	2628 (45%)	49.9 + 14.2 (-)	Positive
Skipper, 2005	Singapore	CL	6 (detail)	466 (44%)	C	60 + 12 (24-81)	65 + 11 (30-91)	466 (44%)	60 + 11 (26-93)	Positive	Submit comment
Tan, 2006	Singapore	CL	1 (detail)	494 (44%)	C	-	64 + 11 (-)	495 (46%)	60 + 10 (-)	Positive	Submit comment
Tan, 2006b	Overlaps with Tan, 2006 (Singapore)	CL	4 (detail)	141 (-)	-	-	-	60 (-)	-	n.a.
Tan, 2008a	Overlaps with Tan, 2006 (Singapore)	CL	1 (detail)	204 (-)	-	61.8 + 10 (-)	66.4 + 10.9 (-)	235 (-)	63.1 + 8.7 (-)	n.a.	Submit comment
Tan, 2008c	Overlaps with Tan, 2006 (Singapore)	CL	1 (detail)	246 (44%)	C	59 + 13 (30-88)	66 + 12 (32-95)	243 (46%)	62 + 10 (30-90)	n.a.	Submit comment
Tan, 2010	China	CL	5 (detail)	628 (41%)	C	56 (16-85)	60 (15-86)	510 (63%)	56 (16-103)	Positive
Tan, 2010 * Recently Updated *	Overlaps with Tan, 2006 (Singapore II)	CL	8 (detail)	192 (43%)	C	59 (31-73)	63 (36-74)	192 (53%)	64 (48-72)	Positive
Tan, 2010	Overlaps with Tan, 2006 (Singapore I)	CL	15 (detail)	250 (47%)	C	61 (29-88)	70 (32-90)	250 (52%)	66 (31-87)	Positive
Tan, 2010	Overlaps with Ross, 2008 (Taiwan I)	CL	5 (detail)	293 (52%)	C	53 (15-81)	62 (21-88)	299 (53%)	62 (22-87)	Positive
Tomiyama, 2008	Japan	CL	1 (detail)	501 (50%)	C	58 + 10.5 (20-88)	65 + 9.6 (28-92)	583 (46%)	45 + 17 (21-98)	Negative	Submit comment
Wu, 2006	China	CL	1 (detail)	598 (38%)	C	64.9 + 10.1 (37-84)	-	765 (-)	65.4 + 13.2 (-)	Positive
Yu, 2009	Overlaps with Tan, 2010 (China)	CL	1 (detail)	328 (46%)	C	52.6 + 12.1 (-)	-	300 (42%)	58.2 + 10.3 (-)	n.a.
Zabetian, 2009	Japan, USA	CL	3 (detail)	631 (58%)	C	60.9 (17-89)	67.1 (22-91)	1641 (55%)	70.1 (37-101)	Positive	Submit comment
Zhang, 2009	Overlaps with Tan, 2010 (China)	CL	1 (detail)	600 (41%)	C	55.9 + 11.1 (20-85)	-	459 (44%)	53.3 + 13.3 (17-91)	n.a.
Zheng, 2010	China	CL	1 (detail)	406 (44%)	C	-	60.7 + 11.9 (18-89)	412 (41%)	59.3 + 10.1 (27-81)	Positive
Other/Mixed
Abdalla-Carvalho, 2010	Brazil	CL	1 (detail)	204 (35%)	C	53.4 + 12.5 (-)	62 + 11.9 (-)	210 (-)	65.4 + 8.9 (-)	Negative
Lesage, 2009	Caribbean	CL	1 (detail)	46 (-)	C	-	-	183 (-)	-	Negative
Tan, 2007	Singapore (Malay)	CL	1 (detail)	98 (-)	C	-	-	173 (-)	-	Negative	Submit comment
Tan, 2007	Sinagapore (Indian)	CL	1 (detail)	66 (-)	C	-	-	133 (-)	-	Negative	Submit comment
Tan, 2008b	Sinagapore (Indian)	CL	1 (detail)	60 (-)	C	-	-	105 (-)	-	Negative	Submit comment
Tan, 2008b	Singapore (Malay)	CL	1 (detail)	132 (-)	C	-	-	160 (-)	-	Negative	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Maraganore, 2005	USA	10 (detail)	443	443 (39%)	C	61 (31-94)	68 (33-96)	443 (52%)	66 (29-90)	Negative	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.