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PDGene - Gene overview of all published PD-association studies for GSTM1
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 Gene: GSTM1  (MU; GSTM1a-1a; GSTM1b-1b; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1)  Entrez Gene    View on AlzGene   View on MSGene   View on SZGene
 Protein: glutathione S-transferase M1   ProteinLink
 Chromosome: 1   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 27 November 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      PD Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Ahmadi, 2000
Sweden (Males) CL,PO  1  (detail)  35
(0%)
C--283
(0%)
49
(30-80)
Positive
Bandmann, 1997
UK CL  1  (detail)  200
(40%)
M-72.6
(-)
100
(35%)
77.1 + 8.8
(-)
Negative
De Palma, 1998
Italy CL  1  (detail)  100
(41%)
C58.6 + 9.7
(-)
66.6 + 9.7
(-)
200
(41%)
64.2 + 9.2
(-)
Positive
De Palma, 2010
Overlaps with
Dick, 2007
CL  1  (detail)  767
(44%)
C-69.8 + 9.2
(-)
1989
(47%)
69.8 + 10
(-)
n.a.
Deng, 2004
Australia CL  1  (detail)  400
(43%)
C60 + 10.7
(-)
-402
(-)
63.9 + 11.4
(-)
Negative
Dick, 2007
Europe CL  1  (detail)  767
(44%)
C61.6 + 9.9
(-)
69.8 + 9.2
(-)
1989
(47%)
69.8 + 10
(-)
Positive
Kelada, 2003
USA CL  1  (detail)  214
(39%)
C-68 + 9.6
(37-88)
330
(36%)
69.3 + 8.6
(44-85)
Negative
Menegon, 1998
Australia CL  1  (detail)  95
(41%)
C-72 + 9
(-)
95
(23%)
67 + 12
(-)
Negative
Nicholl, 1999
UK CL  1  (detail)  206
(41%)
C-64.4
(-)
206
(41%)
63.1
(-)
Negative
Rahbar, 2000
Germany CL  1  (detail)  149
(38%)
C-65.9 + 10
(42-88)
99
(36%)
62.2 + 12.5
(25-91)
Negative
Stroombergen, 1996
Overlaps with
Stroombergen, 1999
CL  1  (detail)  122
(42%)
C-66.3 + 10.7
(-)
84
(54%)
59.8 + 13.3
(-)
n.a.
Stroombergen, 1999
UK CL  1  (detail)  167
(44%)
C-65.1 + 10.4
(-)
225
(55%)
59.2 + 19.8
(-)
Positive
Tison, 1994
France CL  1  (detail)  40
(58%)
C-68
(-)
100
(50%)
-Negative
Vilar, 2007
Portugal CL  1  (detail)  96
(-)
C60.2 + 8.7
(38-77)
68.3 + 7.7
(46-85)
96
(-)
-Negative
Wahner, 2006
USA CL  1  (detail)  235
(46%)
C-69.5
(-)
220
(47%)
67.1
(-)
Negative
 Asian
Harada, 2001
Japan CL  1  (detail)  111
(62%)
C60.9 + 12.4
(-)
68.8 + 8.5
(-)
100
(70%)
43.1 + 12
(-)
Negative
Kiyohara, 2010
Japan CL  1  (detail)  238
(59%)
C-68.5
(64-74)
370
(62%)
66.6
(62-72)
Negative
 Other/Mixed
Biswas, 2011
India CL  1  (detail)  331
(26%)
C48
(-)
-177
(-)
49 + 7
(-)
Negative
Perez-Pastene, 2007
Chile CL  1  (detail)  349
(50%)
C-66.8 + 10.7
(-)
611
(75%)
62 + 13.4
(-)
Positive
Wahner, 2006
USA PO  1  (detail)  54
(46%)
C--50
(54%)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis ->  "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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