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Gene overview of all published PD-association studies for GSTM1

Gene:

GSTM1 (MU; GSTM1a-1a; GSTM1b-1b; H-B; GST1; GTH4; GTM1; MU-1; GSTM1-1)

View on AlzGene View on MSGene View on SZGene

Protein:

glutathione S-transferase M1

Chromosome:

1 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 29 June 2010

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result	Comment
Caucasian
Ahmadi, 2000	Sweden (Males)	CL,PO	1 (detail)	35 (0%)	C	-	-	283 (0%)	49 (30-80)	Positive	Submit comment
Bandmann, 1997	UK	CL	1 (detail)	200 (40%)	M	-	72.6 (-)	100 (35%)	77.1 + 8.8 (-)	Negative	Submit comment
De Palma, 1998	Italy	CL	1 (detail)	100 (41%)	C	58.6 + 9.7 (-)	66.6 + 9.7 (-)	200 (41%)	64.2 + 9.2 (-)	Positive	Submit comment
De Palma, 2010	Overlaps with Dick, 2007	CL	1 (detail)	767 (44%)	C	-	69.8 + 9.2 (-)	1989 (47%)	69.8 + 10 (-)	n.a.
Deng, 2004	Australia	CL	1 (detail)	400 (43%)	C	60 + 10.7 (-)	-	402 (-)	63.9 + 11.4 (-)	Negative	Submit comment
Dick, 2007	Europe	CL	1 (detail)	767 (44%)	C	61.6 + 9.9 (-)	69.8 + 9.2 (-)	1989 (47%)	69.8 + 10 (-)	Positive	Submit comment
Kelada, 2003	USA	CL	1 (detail)	214 (39%)	C	-	68 + 9.6 (37-88)	330 (36%)	69.3 + 8.6 (44-85)	Negative	Submit comment
Menegon, 1998	Australia	CL	1 (detail)	95 (41%)	C	-	72 + 9 (-)	95 (23%)	67 + 12 (-)	Negative	Submit comment
Nicholl, 1999	UK	CL	1 (detail)	206 (41%)	C	-	64.4 (-)	206 (41%)	63.1 (-)	Negative	Submit comment
Rahbar, 2000	Germany	CL	1 (detail)	149 (38%)	C	-	65.9 + 10 (42-88)	99 (36%)	62.2 + 12.5 (25-91)	Negative	Submit comment
Stroombergen, 1996	Overlaps with Stroombergen, 1999	CL	1 (detail)	122 (42%)	C	-	66.3 + 10.7 (-)	84 (54%)	59.8 + 13.3 (-)	n.a.	Submit comment
Stroombergen, 1999	UK	CL	1 (detail)	167 (44%)	C	-	65.1 + 10.4 (-)	225 (55%)	59.2 + 19.8 (-)	Positive	Submit comment
Tison, 1994	France	CL	1 (detail)	40 (58%)	C	-	68 (-)	100 (50%)	-	Negative
Vilar, 2007	Portugal	CL	1 (detail)	96 (-)	C	60.2 + 8.7 (38-77)	68.3 + 7.7 (46-85)	96 (-)	-	Negative	Submit comment
Wahner, 2006	USA	CL	1 (detail)	235 (46%)	C	-	69.5 (-)	220 (47%)	67.1 (-)	Negative	Submit comment
Asian
Harada, 2001	Japan	CL	1 (detail)	111 (62%)	C	60.9 + 12.4 (-)	68.8 + 8.5 (-)	100 (70%)	43.1 + 12 (-)	Negative	Submit comment
Kiyohara, 2010	Japan	CL	1 (detail)	238 (59%)	C	-	68.5 (64-74)	370 (62%)	66.6 (62-72)	Negative
Other/Mixed
Perez-Pastene, 2007	Chile	CL	1 (detail)	349 (50%)	C	-	66.8 + 10.7 (-)	611 (75%)	62 + 13.4 (-)	Positive	Submit comment
Wahner, 2006	USA	PO	1 (detail)	54 (46%)	C	-	-	50 (54%)	-	Negative	Submit comment

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.