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Gene overview of all published PD-association studies for UCHL1
Back Search Methods Disclaimer Credits
 Gene: UCHL1  (Uch-L1; PARK5; PGP9.5)  Entrez Gene    View on AlzGene
 Protein: ubiquitin carboxyl-terminal esterase L1  (ubiquitin thiolesterase)  ProteinLink
 Chromosome: 4   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 2 October 2011
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      PD Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result
 Caucasian
Carmine, 2007
 Sweden CL  1  (detail)  296
(-)		C60
(-)		68
(-)		235
(-)		57
(-)		Positive
Chung, 2010
 USA CL  11  (detail)  449
(35%)		-64.7
(23-88)		70.3
(44-90)		449
(35%)		71.8
(45-93)		Trend
Elbaz, 2003
 France CO  1  (detail)  209
(43%)		C65
(35-75)		68
(37-75)		488
(41%)		68
(36-79)		Positive
Facheris, 2005
 Overlaps with
Chung, 2010 (USA)		 CL  1  (detail)  70
(-)		C--70
(-)		-n.a.
Fung, 2006
 Overlaps with
Simon-Sanchez, 2009 (USA-NINDS)		 CL  1  (detail)  267
(-)		C--270
(-)		68
(55-88)		n.a.
Healy, 2006
 UK, Ireland CL  3  (detail)  1536
(-)		M58.3
(-)		-1487
(-)		56.1
(-)		Negative
Hutter, 2007
 USA CL  1  (detail)  1757
(32%)		C58.7 + 11.6
(-)		68 + 10.5
(-)		2016
(63%)		67.4 + 18.2
(-)		Negative
Levecque, 2001
 France CL  1  (detail)  114
(53%)		C58.7 + 11.3
(-)		66.5 + 10.6
(-)		93
(51%)		66.9 + 9.5
(-)		Negative
Maraganore, 1999
 Overlaps with
Chung, 2010 (USA)		 CL  1  (detail)  139
(35%)		C62
(31-82)		69
(39-91)		113
(65%)		72
(37-90)		n.a.
Maraganore, 2003
 Overlaps with
Chung, 2010 (USA)		 CL  1  (detail)  298
(38%)		C63.4
(31-85)		69.8
(33-99)		185
(63%)		72.1
(37-94)		n.a.
McCulloch, 2008
 Overlaps with
Hutter, 2007 (USA-Washington)		 CL  1  (detail)  391
(26%)		C-67.3
(32-95)		293
(58%)		67.3
(30-93)		n.a.
McCulloch, 2008
 Overlaps with
Hutter, 2007 (USA-Oregon)		 CL  1  (detail)  172
(38%)		C-65.9
(39-87)		96
(55%)		67.8
(21-83)		n.a.
McCulloch, 2008
 Overlaps with
Hutter, 2007 (USA-NY)		 CL  1  (detail)  253
(35%)		C-68.1
(40-95)		214
(66%)		64.6
(34-94)		n.a.
McCulloch, 2008
 Overlaps with
Hutter, 2007 (USA-Georgia)		 CL  1  (detail)  116
(37%)		C-67.3
(40-97)		61
(67%)		68.5
(51-84)		n.a.
Mellick, 2000
 Australia CL  1  (detail)  142
(51%)		C59 + 11
(32-83)		66 + 11
(37-85)		142
(51%)		66 + 10
(39-86)		Negative
Pankratz, 2008
 USA (PROGENI, GenePD) CL  13  (detail)  857
(41%)		C61.9 + 10.8
(-)		-867
(60%)		54.8 + 13.1
(-)		Negative
Savettieri, 2001
 Italy CL  1  (detail)  169
(41%)		C59
(37-84)		67
(43-87)		165
(55%)		73
(60-96)		Negative
Simon-Sanchez, 2009
 USA (NINDS-GWAS) CL  12  (detail)  931
(40%)		C--790
(58%)		-Negative
Simon-Sanchez, 2009
 USA, Germany (GWAS) CL,PO  1  (detail)  1745
(45%)		C55.8
(7-98)		-4047
(50%)		-Negative
Sutherland, 2009
 Australia CL  3  (detail)  331
(51%)		C60.1 + 10.6
(-)		70.3 + 8.7
(-)		296
(51%)		70.5 + 8.9
(-)		Trend
Wintermeyer, 2000
 Germany CL  1  (detail)  229
(44%)		C-66.3 + 10.8
(-)		200
(48%)		72 + 4.3
(-)		Positive
Xiromerisiou, 2011
 Greece CL  5  (detail)  399
(42%)		U65 + 9.6
(-)		69.4 + 8.7
(-)		420
(45%)		69 + 12.8
(-)		Negative
Zhang, 2000
 USA CL  1  (detail)  153
(-)		M60.6 + 8.8
(-)		-142
(-)		72.5
(-)		Negative
 Asian
Mizuta, 2006
 Overlaps with
Mizuta, 2008		 CL  4  (detail)  882
(56%)		C57.4 + 10.9
(-)		64.9 + 9.8
(-)		938
(48%)		45.3 + 16.3
(-)		Negative
Mizuta, 2008
 Japan CL  1  (detail)  882
(56%)		C57.4 + 10.9
(-)		64.9 + 9.8
(-)		938
(48%)		45.6 + 16.3
(-)		Negative
Momose, 2002
 Overlaps with
Mizuta, 2008		 CL  1  (detail)  232
(51%)		C54.1 + 10.5
(24-80)		-249
(49%)		-n.a.
Satoh, 2001
 Japan CL  1  (detail)  74
(62%)		C-69 + 8.8
(46-86)		155
(49%)		66.4 + 11.8
(40-88)		Positive
Snapinn, 2011
 Japan, USA CL,PO  1  (detail)  605
(57%)		C61 + 10.8
(-)		67.1 + 10.3
(-)		1620
(55%)		70.3 + 6.9
(-)		Trend
Tan, 2006
 Overlaps with
Tan-Singapore (Tan), 2009		 CL  1  (detail)  335
(44%)		C61 + 11
(-)		65 + 10
(30-89)		341
(47%)		61 + 11
(26-93)		n.a.
Tan, 2009
 China (Lu) CL  1  (detail)  608
(-)		C--386
(-)		-Negative
Tan, 2009
 China (Robin) CL  1  (detail)  252
(-)		C--231
(-)		-Negative
Tan, 2009
 China (Peng) CL  1  (detail)  600
(-)		C--334
(-)		-Negative
Tan, 2009
 Singapore (Tan) CL  1  (detail)  441
(-)		C--449
(-)		-Trend
Tan, 2009
 Overlaps with
Wu, 2010		 CL  1  (detail)  242
(-)		C--363
(-)		-n.a.
Toda, 2003
 Overlaps with
Mizuta, 2008		 CL  1  (detail)  232
(51%)		C54.1 + 10.5
(24-80)		-249
(49%)		-n.a.
Wang, 2002
 China CL  1  (detail)  160
(44%)		C58.8 + 12.6
(30-82)		66.8 + 11.2
(34-86)		160
(44%)		65.9 + 12.8
(34-86)		Positive
Wang, 2011
 China CL  1  (detail)  408
(43%)		C53.7 + 11.7
(9-78)		54.3 + 12.2
(10-79)		398
(45%)		50.4 + 15.8
(8-83)		Negative
Wu, 2010
 Taiwan CL  1  (detail)  517
(44%)		C62.7 + 11.3
(19-86)		-518
(48%)		59 + 13.3
(28-94)		Positive
Zhang, 2000
 Japan CL  1  (detail)  160
(-)		C55.4 + 10.7
(-)		-160
(-)		58.1
(-)		Positive
Zhang, 2008
 Overlaps with
Tan-China (Peng), 2009		 CL  1  (detail)  600
(41%)		C55.9 + 11.6
(20-85)		-334
(46%)		53.5 + 13.7
(24-91)		n.a.
 Other/Mixed
Benitez, 2010
 Colombia CL  1  (detail)  104
(49%)		C53.7 + 13.4
(-)		60.1 + 12.6
(-)		136
(54%)		62.4 + 9.5
(-)		Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)		 DX Onset Age
(range)		 Age
(range)		 # Subjects
(% women)		 Age
(range)		 Result
 Caucasian
Chung, 2010
 USA  11  (detail)   654
(36%)		C60.4
(28-87)		66.3 + 30.8
(-)		654
(50%)		65.1
(32-90)		Trend
Facheris, 2005
 Overlaps with
Maraganore, 1999		  1  (detail)   427
(-)		C--427
(-)		-Positive
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis ->  "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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PDGene Stats
Studies: 881
Genes: 915
Polymorphisms: 3446
Meta-analyses: 889
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