PDGene

Gene overview of all published PD-association studies for MCCC1

Gene:

MCCC1 (DKFZp686B20267; FLJ25545; MCC-B; MCCA)

Protein:

methylcrotonoyl-CoA carboxylase 1 (alpha) (3-methylcrotonyl-CoA carboxylase 1; 3-methylcrotonyl-CoA carboxylase biotin-containing subunit; 3-methylcrotonyl-CoA:carbon dioxide ligase subunit alpha; MCCase subunit alpha; OTTHUMP00000212828; OTTHUMP00000212829; OTTHUMP00000212832; methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial; methylcrotonoyl-Coenzyme A carboxylase 1 (alpha))

Chromosome:

3 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 10 August 2011

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Do, 2011	USA (23andMe-GWAS)	CL	1 (detail)	3426 (40%)	M	57.4 + 10.7 (-)	64.3 + 10.6 (-)	29624 (42%)	48.2 + 16 (-)	Positive
IPDGC, 2011	France (GWAS)	CL,PO	1 (detail)	1039 (41%)	U	48.9 + 48.9 (-)	-	1984 (33%)	73.7 + 5.4 (-)	Positive
IPDGC, 2011	France (REP-Immuno)	CL	1 (detail)	267 (-)	U	-	-	363 (-)	-	Positive
IPDGC, 2011	Germany (REP-Immuno)	CL	1 (detail)	1153 (-)	U	-	-	712 (-)	-	Positive
IPDGC, 2011	Iceland (REP-in silico)	CL,PO	1 (detail)	479 (-)	C	-	-	1427 (-)	-	Positive
IPDGC, 2011	Netherlands (REP-in silico)	CL,PO	1 (detail)	824 (-)	U	-	-	2082 (-)	-	Positive
IPDGC, 2011	UK (REP-Immuno)	CL	1 (detail)	1271 (-)	U	-	-	1864 (-)	-	Positive
IPDGC, 2011	USA (PROGENI/GenePD-GWAS)	CL	1 (detail)	876 (40%)	U	61.5 + 61.5 (-)	-	857 (60%)	-	Positive
IPDGC, 2011	USA (NINDS-GWAS)	CL	1 (detail)	971 (40%)	U	55.9 + 55.9 (-)	-	3034 (53%)	62 + 15.6 (-)	Positive
IPDGC, 2011	USA (REP-Immuno)	CL	1 (detail)	2807 (-)	U	-	-	2215 (-)	-	Positive
IPDGC, 2011	Germany (GWAS)	CL	1 (detail)	742 (40%)	U	56 + 56 (-)	-	944 (48%)	-	Positive
IPDGC, 2011	Netherlands (REP-Immuno)	CL	1 (detail)	304 (-)	U	-	-	402 (-)	-	Positive
IPDGC, 2011	UK (WTCCC-GWAS)	CL,PO	1 (detail)	1705 (43%)	U	-	-	5200 (50%)	-	Positive

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.