PDGene

Gene overview of all published PD-association studies for BDNF

Gene:

BDNF (MGC34632)

View on AlzGene View on MSGene View on SZGene

Protein:

brain-derived neurotrophic factor (neurotrophin)

Chromosome:

11 (View: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 X Y MT)

Status:

Updated 27 November 2011

1. Case-Control Studies (by ethnic group)
				PD Cases				Normal Controls
Study	Population	Source	# Polys	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Cramer, 2009	USA	CL	1 (detail)	53 (36%)	C	-	65 + 10 (-)	54 (-)	55 + 15 (-)	Negative
Fung, 2006	Overlaps with Simon-Sanchez, 2009 (USA)	CL	4 (detail)	267 (-)	C	-	-	270 (-)	68 (55-88)	n.a.
Gao, 2010	Spain	CL	1 (detail)	193 (42%)	-	56.9 + 12 (-)	66.1 + 10.4 (-)	300 (38%)	61.7 + 12.2 (-)	Negative
Guerini, 2009	Italy	CL	1 (detail)	294 (46%)	C	61.2 (-)	69.5 (33-86)	233 (66%)	61.5 (26-86)	Positive
Hakansson, 2003	Sweden	CL	1 (detail)	257 (-)	C	60 (-)	-	307 (-)	-	Negative
Karakasis, 2011	Greece	CL	1 (detail)	184 (-)	C	-	63.9 + 0.7 (-)	113 (-)	71.6 + 0.5 (-)	Negative
Karamohamed, 2005	Overlaps with Parsian, 2004	CL	5 (detail)	597 (-)	C	-	-	130 (-)	-	Positive
Liu, 2005	USA	CL	3 (detail)	600 (-)	C	-	-	280 (-)	-	n.a.
Pankratz, 2008	USA (PROGENI, GenePD)	CL	9 (detail)	857 (41%)	C	61.9 + 10.8 (-)	-	867 (60%)	54.8 + 13.1 (-)	Negative
Parsian, 2004	USA	CL	2 (detail)	358 (35%)	C	60 (21-85)	67.6 (-)	195 (35%)	62 + 14 (-)	Positive
Saarela, 2006	Finland	CL	2 (detail)	52 (52%)	M	76.2 + 6 (-)	-	101 (55%)	79 + 9.3 (-)	Negative
Simon-Sanchez, 2009	USA, Germany (GWAS)	CL,PO	2 (detail)	1745 (45%)	C	55.8 (7-98)	-	4047 (50%)	-	Negative
Simon-Sanchez, 2009	USA (NINDS-GWAS)	CL	7 (detail)	931 (40%)	C	-	-	790 (58%)	-	Negative
Xiromerisiou, 2007	Greece	CL	8 (detail)	242 (41%)	C	63.3 + 9.6 (-)	69.8 + 8.7 (-)	203 (46%)	68.3 + 12.8 (-)	Negative
Xiromerisiou, 2007	Overlaps with Simon-Sanchez, 2009 (USA)	CL	8 (detail)	271 (46%)	C	55 + 15.1 (-)	63 + 13.3 (-)	231 (44%)	68.7 + 15.2 (-)	n.a.
Xiromerisiou, 2007	Finland	CL	8 (detail)	145 (41%)	C	61.1 + 8.5 (-)	66.8 + 8.6 (-)	133 (36%)	66.6 + 9.1 (-)	Negative
Asian
Chen, 2007	Taiwan	CL	1 (detail)	356 (46%)	C	63.5 + 9.2 (41-84)	69.2 + 9.1 (-)	325 (48%)	62.6 + 10.4 (40-94)	Negative
Chen, 2011	China	CL	4 (detail)	266 (35%)	C	-	65 + 10.5 (-)	400 (59%)	64.5 + 5.7 (-)	Positive
Hong, 2003	Taiwan	CL	1 (detail)	107 (28%)	C	64 + 11.4 (-)	68.2 + 10.4 (-)	103 (33%)	66.3 + 14.2 (-)	Negative
Lin, 2010	Taiwan	CL	1 (detail)	453 (43%)	C	-	57.9 + 11.7 (-)	291 (56%)	59.2 + 14.6 (-)	Positive
Masaki, 2003	Japan	CL	1 (detail)	291 (-)	C	-	65.7 + 8.9 (-)	291 (-)	65.6 + 9.2 (-)	Positive
Mizuta, 2006	Overlaps with Momose, 2002	CL	1 (detail)	190 (-)	C	-	-	190 (-)	-	n.a.
Momose, 2002	Japan	CL	1 (detail)	232 (51%)	C	54.1 + 10.5 (24-80)	-	249 (49%)	-	Positive
Nishimura, 2005	Japan	CL	2 (detail)	327 (61%)	C	-	66.4 + 9.9 (35-88)	275 (61%)	68.4 + 10.5 (35-92)	Negative
Toda, 2003	Overlaps with Momose, 2002	CL	1 (detail)	232 (51%)	C	54.1 + 10.5 (24-80)	-	249 (49%)	-	n.a.
Other/Mixed
Benitez, 2010	Colombia	CL	1 (detail)	104 (49%)	C	53.7 + 13.4 (-)	60.1 + 12.6 (-)	136 (54%)	62.4 + 9.5 (-)	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

2. Family-Based Studies (by ethnic group)
				Affecteds				Unaffecteds
Study	Population	# Polys	# Families	# Subjects (% women)	DX	Onset Age (range)	Age (range)	# Subjects (% women)	Age (range)	Result
Caucasian
Liu, 2005	Overlaps with Liu, 2005 (CC)	3 (detail)		600 (-)	C	-	-	320 (-)	-	Negative
Maraganore, 2005	USA	1 (detail)	443	443 (39%)	C	61 (31-94)	68 (33-96)	443 (52%)	66 (29-90)	Negative

Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.

Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis -> "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.