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PDGene - Gene overview of all published PD-association studies for LRRK2
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 Gene: LRRK2  (PARK8; ROCO2)  Entrez Gene    View on AlzGene
 Protein: leucine-rich repeat kinase 2  (dardarin)  ProteinLink
 Chromosome: 12   (View: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  15  16  17  18  19  20  21  22  X  Y  MT)
 Status: Updated 17 December 2012
Meta-Analysis
1. Case-Control Studies (by ethnic group)
      PD Cases Normal Controls  
Study Population Source # Polys # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Biskup, 2005
Overlaps with
Simon-Sanchez, 2009 (Germany)
CL  97  (detail)  340
(42%)
C52
(-)
-680
(-)
-Negative
Biskup, 2005
Overlaps with
Simon-Sanchez, 2009 (Germany)
CL  6  (detail)  322
(-)
C--322
(-)
-Negative
Chung, 2010
USA CL  65  (detail)  449
(35%)
-64.7
(23-88)
70.3
(44-90)
449
(35%)
71.8
(45-93)
Trend
Clark, 2006
USA CL  11  (detail)  504
(40%)
C53.8
(-)
61.8 + 12.5
(-)
314
(43%)
66.5 + 11.4
(-)
Positive
Dupre, 2007
Canada CL  6  (detail)  125
(29%)
C55.3
(30-79)
-95
(-)
-Negative
Fung, 2006
Overlaps with
Simon-Sanchez, 2009 (USA)
CL  59  (detail)  267
(-)
C--270
(-)
68
(55-88)
n.a.
Hamza, 2010
USA (NGRC-GWAS) CL  6  (detail)  2000
(33%)
C58.3 + 11.9
(-)
67.2 + 10.6
(-)
1986
(61%)
70.3 + 14
(21-90)
Positive
IPDGC, 2011
France (GWAS) CL,PO  1  (detail)  1039
(41%)
U48.9 + 48.9
(-)
-1984
(33%)
73.7 + 5.4
(-)
Positive
IPDGC, 2011
France (REP-Immuno) CL  1  (detail)  267
(-)
U--363
(-)
-Positive
IPDGC, 2011
Germany (REP-Immuno) CL  1  (detail)  1153
(-)
U--712
(-)
-Positive
IPDGC, 2011
Iceland (REP-in silico) CL,PO  1  (detail)  479
(-)
C--1427
(-)
-Positive
IPDGC, 2011
Netherlands (REP-in silico) CL,PO  1  (detail)  824
(-)
U--2082
(-)
-Positive
IPDGC, 2011
UK (REP-Immuno) CL  1  (detail)  1271
(-)
U--1864
(-)
-Positive
IPDGC, 2011
USA (PROGENI/GenePD-GWAS) CL  1  (detail)  876
(40%)
U61.5 + 61.5
(-)
-857
(60%)
-Positive
IPDGC, 2011
USA (NINDS-GWAS) CL  1  (detail)  971
(40%)
U55.9 + 55.9
(-)
-3034
(53%)
62 + 15.6
(-)
Positive
IPDGC, 2011
USA (REP-Immuno) CL  1  (detail)  2807
(-)
U--2215
(-)
-Positive
IPDGC, 2011
Germany (GWAS) CL  1  (detail)  742
(40%)
U56 + 56
(-)
-944
(48%)
-Positive
IPDGC, 2011
Netherlands (REP-Immuno) CL  1  (detail)  304
(-)
U--402
(-)
-Positive
IPDGC, 2011
UK (WTCCC-GWAS) CL,PO  1  (detail)  1705
(43%)
U--5200
(50%)
-Positive
Lesage, 2009
Mixed CL  1  (detail)  220
(-)
C--174
(-)
-Negative
Lu, 2008
Netherlands CL  1  (detail)  106
(-)
C--96
(-)
-Positive
Maraganore, 2005
USA CL  1  (detail)  332
(42%)
C63
(36-88)
68
(42-90)
332
(42%)
67
(42-91)
Negative
Nuytemans, 2009
Belgium CL  16  (detail)  310
(42%)
C60.1 + 11.3
(-)
-363
(47%)
67 + 10
(-)
n.a.
Ozelius, 2006
USA (Ashkenazi) CL  5  (detail)  120
(-)
C----Positive
Paisan-Ruiz, 2005
Canada CL  4  (detail)  121
(40%)
C37.9 + 10.8
(14-65)
56.9 + 11.7
(33-83)
250
(59%)
73.3 + 8.5
(58-96)
Negative
Paisan-Ruiz, 2006
Finland CL  36  (detail)  147
(41%)
C-67.2
(38-88)
136
(63%)
65.8
(37-87)
Negative
Paisan-Ruiz, 2006
Greece CL  36  (detail)  217
(40%)
C63.3 + 9.6
(30-88)
69.8 + 8.7
(44-95)
221
(44%)
68.3 + 12.8
(32-93)
Negative
Paisan-Ruiz, 2008
Overlaps with
Simon-Sanchez, 2009 (USA)
CL  87  (detail)  272
(50%)
C--275
(52%)
68
(55-88)
Negative
Paisan-Ruiz, 2009
Re-analysis of Fung, 2006 CL  0  ------n.a.
Pankratz, 2008
USA (PROGENI, GenePD) CL  183  (detail)  857
(41%)
C61.9 + 10.8
(-)
-867
(60%)
54.8 + 13.1
(-)
Negative
Patra, 2008
USA CL  6  (detail)  575
(42%)
C60.2
(22-82)
68
(-)
186
(61%)
62 + 14
(-)
Negative
Saad, 2010
France (GWAS) CL  4  (detail)  1039
(41%)
C48.9 + 12.8
(-)
57.5 + 16.6
(-)
1984
(43%)
73.7 + 5.4
(-)
Trend
Simon-Sanchez, 2009
USA, Germany, UK (Stage II) CL,PO  3  (detail)  3452
(32%)
M61.1
(-)
-4756
(39%)
-Positive
Simon-Sanchez, 2009
USA, Germany (GWAS) CL,PO  50  (detail)  1745
(45%)
C55.8
(7-98)
-4047
(50%)
-Positive
Simon-Sanchez, 2009
USA (NINDS-GWAS) CL  133  (detail)  931
(40%)
C--790
(58%)
-Positive
Simon-Sanchez, 2011
Netherlands (GWAS) CL,PO  1  (detail)  772
(36%)
U55.3
(16-84)
62.3
(29-89)
2024
(56%)
53.7
(45-95)
Positive
Spencer, 2010
UK (WTCCC2-GWAS) CL,PO  1  (detail)  1705
(-)
C--5175
(-)
-Negative
Sutherland, 2009
Australia CL  24  (detail)  331
(51%)
C60.1 + 10.6
(-)
70.3 + 8.7
(-)
296
(51%)
70.5 + 8.9
(-)
Trend
Toft, 2007a
Spain CL  1  (detail)  205
(-)
C-66 + 13
(-)
205
(-)
-Negative
Toft, 2007a
Norway CL  1  (detail)  388
(-)
C-70 + 11
(-)
338
(-)
-Negative
Toft, 2007a
Ireland CL  1  (detail)  186
(-)
C-61 + 13
(-)
186
(-)
-Negative
Toft, 2007b
Norway CL  1  (detail)  433
(-)
C58 + 11
(25-88)
71 + 11
(43-97)
587
(-)
69 + 12
(41-104)
Negative
 African Descent
Ross, 2010
USA CL  14  (detail)  22
(55%)
C50.6
(27-65)
58.7
(40-72)
92
(73%)
41.9
(20-71)
Negative
 Asian
An, 2008
Overlaps with
Tan, 2010 (China)
CL  1  (detail)  600
(41%)
C-55.9
(20-85)
334
(46%)
53.6 + 13.8
(24-91)
n.a.
Chan, 2008
China CL  1  (detail)  82
(46%)
C56.9
(17-95)
63.8
(-)
31
(-)
70.4 + 9.2
(44-82)
Positive
Chang, 2011
China CL  3  (detail)  636
(41%)
C55.8 + 11.1
(17-85)
-510
(43%)
52.4 + 14
(15-91)
Positive
Chen, 2010
China CL  1  (detail)  430
(42%)
U-60.7 + 11.5
(17-90)
452
(41%)
59.2 + 9
(27-81)
Trend
Choi, 2008
Korea CL  1  (detail)  72
(53%)
C38.8 + 7
(13-50)
-100
(-)
-Positive
Di Fonzo, 2006
Taiwan CL  2  (detail)  608
(40%)
C54.9 + 11.9
(12-94)
66 + 12
(24-97)
373
(57%)
54.7 + 18.2
(11-87)
Positive
Farrer, 2007
Overlaps with
Lin, 2010
CL  1  (detail)  410
(43%)
C57.7
(-)
-335
(-)
-n.a.
Funayama, 2007
Japan CL  1  (detail)  448
(52%)
C50.7 + 14.6
(5-89)
59.4 + 13.8
(15-93)
457
(47%)
43.8 + 16
(21-98)
Positive
Fung, 2006
Taiwan CL  1  (detail)  305
(46%)
C61.8 + 10.6
(30-91)
-176
(46%)
59.6 + 9.6
(38-86)
Positive
Kim, 2009
South Korea CL  2  (detail)  923
(56%)
C54.8 + 10.9
(18-85)
63.7 + 9.9
(22-91)
422
(55%)
61.9 + 9.5
(37-85)
Positive
Li, 2007
China CL  1  (detail)  235
(43%)
C54.6 + 13.3
(14-88)
62.6 + 11.4
(15-88)
214
(43%)
52.9 + 11.7
(15-80)
Positive
Lin, 2010
Overlaps with
Ross, 2008 (Taiwan)
CL  6  (detail)  453
(43%)
C-57.9 + 11.7
(-)
291
(56%)
59.2 + 14.6
(-)
Positive
Lu, 2008
Taiwan CL  4  (detail)  834
(41%)
C55.6 + 12.1
(12-94)
65.7 + 11.8
(24-97)
543
(59%)
51.9 + 18.4
(11-87)
Positive
Miyake, 2010
Japan CL  1  (detail)  229
(62%)
C-68.4 + 8.7
(-)
358
(61%)
66.6 + 8.5
(-)
Positive
Pulkes, 2010
Thailand CL  2  (detail)  154
(44%)
C61.2 + 9.8
(-)
-156
(-)
-Positive
Ross, 2008
Overlaps with
Tan, 2006 (Singapore)
CL  1  (detail)  250
(-)
C--250
(-)
-n.a.
Ross, 2008
Taiwan (I) CL  1  (detail)  484
(-)
C--341
(-)
-Positive
Ross, 2008
Taiwan (II) CL  1  (detail)  345
(-)
C--316
(-)
-Positive
Ross, 2008
Japan CL  1  (detail)  151
(-)
C--95
(-)
-Negative
Satake, 2009
Japan (Replication-2) CL  5  (detail)  321
(55%)
C63.7 + 9.7
(-)
-1614
(55%)
59.1 + 19.1
(-)
Positive
Satake, 2009
Japan (Replication-1) CL  5  (detail)  612
(50%)
C43 + 13.8
(20-80)
-14139
(42%)
60.1 + 12.6
(-)
Positive
Satake, 2009
Japan (GWAS) CL  5  (detail)  1078
(55%)
C-58.8 + 10.1
(22-88)
2628
(45%)
49.9 + 14.2
(-)
Positive
Seki, 2011
Overlaps with
Funayama, 2007 (Japan)
CL  1  (detail)  184
(-)
C--233
(-)
-n.a.
Skipper, 2005
Singapore CL  6  (detail)  466
(44%)
C60 + 12
(24-81)
65 + 11
(30-91)
466
(44%)
60 + 11
(26-93)
Positive
Tan, 2006
Singapore CL  1  (detail)  494
(44%)
C-64 + 11
(-)
495
(46%)
60 + 10
(-)
Positive
Tan, 2006b
Overlaps with
Tan, 2006 (Singapore)
CL  4  (detail)  141
(-)
---60
(-)
-n.a.
Tan, 2008a
Overlaps with
Tan, 2006 (Singapore)
CL  1  (detail)  204
(-)
-61.8 + 10
(-)
66.4 + 10.9
(-)
235
(-)
63.1 + 8.7
(-)
n.a.
Tan, 2008c
Overlaps with
Tan, 2006 (Singapore)
CL  1  (detail)  246
(44%)
C59 + 13
(30-88)
66 + 12
(32-95)
243
(46%)
62 + 10
(30-90)
n.a.
Tan, 2010
China CL  5  (detail)  628
(41%)
C56
(16-85)
60
(15-86)
510
(63%)
56
(16-103)
Positive
Tan, 2010
Overlaps with
Tan, 2006 (Singapore II)
CL  8  (detail)  192
(43%)
C59
(31-73)
63
(36-74)
192
(53%)
64
(48-72)
Positive
Tan, 2010
Overlaps with
Tan, 2006 (Singapore I)
CL  15  (detail)  250
(47%)
C61
(29-88)
70
(32-90)
250
(52%)
66
(31-87)
Positive
Tan, 2010
Overlaps with
Ross, 2008 (Taiwan I)
CL  5  (detail)  293
(52%)
C53
(15-81)
62
(21-88)
299
(53%)
62
(22-87)
Positive
Tomiyama, 2008
Japan CL  1  (detail)  501
(50%)
C58 + 10.5
(20-88)
65 + 9.6
(28-92)
583
(46%)
45 + 17
(21-98)
Negative
Wang, 2012
China CL,PO  2  (detail)  2013
(39%)
C58.6 + 10.4
(-)
62.7 + 10.1
(-)
1971
(42%)
64.9 + 8.3
(-)
Positive
Wu, 2006
China CL  1  (detail)  598
(38%)
C64.9 + 10.1
(37-84)
-765
(-)
65.4 + 13.2
(-)
Positive
Yao, 2011
China CL  1  (detail)  401
(41%)
C54.8 + 11.2
(-)
-398
(47%)
53.4 + 13
(-)
Negative
Yu, 2009
Overlaps with
Tan, 2010 (China)
CL  1  (detail)  328
(46%)
C52.6 + 12.1
(-)
-300
(42%)
58.2 + 10.3
(-)
n.a.
Zabetian, 2009
Japan, USA CL  3  (detail)  631
(58%)
C60.9
(17-89)
67.1
(22-91)
1641
(55%)
70.1
(37-101)
Positive
Zhang, 2009
Overlaps with
Tan, 2010 (China)
CL  1  (detail)  600
(41%)
C55.9 + 11.1
(20-85)
-459
(44%)
53.3 + 13.3
(17-91)
n.a.
Zheng, 2010
China CL  1  (detail)  406
(44%)
C-60.7 + 11.9
(18-89)
412
(41%)
59.3 + 10.1
(27-81)
Positive
 Other/Mixed
Abdalla-Carvalho, 2010
Brazil CL  1  (detail)  204
(35%)
C53.4 + 12.5
(-)
62 + 11.9
(-)
210
(-)
65.4 + 8.9
(-)
Negative
Jasinska-Myga, 2010
Tunisia CL  18  (detail)  240
(52%)
C42 + 16
(20-82)
66 + 12
(27-87)
372
(49%)
58 + 11
(31-92)
Trend
Lesage, 2009
Caribbean CL  1  (detail)  46
(-)
C--183
(-)
-Negative
Tan, 2007
Singapore (Malay) CL  1  (detail)  98
(-)
C--173
(-)
-Negative
Tan, 2007
Sinagapore (Indian) CL  1  (detail)  66
(-)
C--133
(-)
-Negative
Tan, 2008b
Sinagapore (Indian) CL  1  (detail)  60
(-)
C--105
(-)
-Negative
Tan, 2008b
Singapore (Malay) CL  1  (detail)  132
(-)
C--160
(-)
-Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
2. Family-Based Studies (by ethnic group)
      Affecteds Unaffecteds  
Study Population # Polys # Families # Subjects
(% women)
DX Onset Age
(range)
Age
(range)
# Subjects
(% women)
Age
(range)
Result
 Caucasian
Chung, 2010
USA  65  (detail)   654
(36%)
C60.4
(28-87)
66.3 + 30.8
(-)
654
(50%)
65.1
(32-90)
Trend
Maraganore, 2005
USA  9  (detail)  443443
(39%)
C61
(31-94)
68
(33-96)
443
(52%)
66
(29-90)
Negative
Maraganore, 2005
Overlaps with
Chung, 2010 (USA)
 24  (detail)  443443
(39%)
C61
(31-94)
68
(33-96)
443
(52%)
66
(29-90)
Negative
Contact us if you are an author of an association study regarding this gene and do not find your study in this table or find errors in the representation of your study details.
Source:  Source of case population -> “CL” (clinic-based), “PO” (population-based), or “CO” (community-based).
# Polys:  Number of polymorphisms tested per gene and per sample.
Onset Age and Age:  Mean or median age at onset or examination, respectively.
DX:  Criteria used to determine PD diagnosis ->  "C" (clinical PD diagnosis), "N" (neuropathological PD diagnosis), "M" (mixed, i.e. PD sample contains both clinical and neuropathological cases), "U" (unknown).
Result:  Overall conclusion reached by authors of the original publication (“positive” usually indicates significant (P<0.05) association in at least one of the performed analyses, and “negative” indicates no evidence for significant association, while “trend” indicates results in between).
(-) :  Either no data provided or in case of overlap, data included in original study.
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